# Within the MDT Room: Situated in Multidisciplinary Team-Grounded Agent Debate for Clinical Diagnosis

arXiv: https://arxiv.org/abs/2603.28393 · HTML: https://mlsanity.com/paper/2603.28393/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and scientific domain agents, one of 16 directions in LLM agents and tool use.
- Builds on 25 of its 54 references that are in the map.
- First posted on arXiv 30 Mar 2026.

## Placed in

- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 25 of 25)

- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [A Survey on Large Language Model based Autonomous Agents](https://mlsanity.com/paper/2308.11432/) (2023)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [MedAgents: Large Language Models as Collaborators for Zero-shot Medical Reasoning](https://mlsanity.com/paper/2311.10537/) (2023)
- [Towards Accurate Differential Diagnosis with Large Language Models](https://mlsanity.com/paper/2312.00164/) (2023)
- [Human-Centered Tools for Coping with Imperfect Algorithms during Medical Decision-Making](https://mlsanity.com/paper/1902.02960/) (2019)
- [AI Hospital: Benchmarking Large Language Models in a Multi-agent Medical Interaction Simulator](https://mlsanity.com/paper/2402.09742/) (2024)
- [Interactive Debugging and Steering of Multi-Agent AI Systems](https://mlsanity.com/paper/2503.02068/) (2025)
- [Graphologue: Exploring Large Language Model Responses with Interactive Diagrams](https://mlsanity.com/paper/2305.11473/) (2023)
- [Unremarkable AI: Fitting Intelligent Decision Support into Critical, Clinical Decision-Making Processes](https://mlsanity.com/paper/1904.09612/) (2019)
- [An Agentic System for Rare Disease Diagnosis with Traceable Reasoning](https://mlsanity.com/paper/2506.20430/) (2025)
- [Sensecape: Enabling Multilevel Exploration and Sensemaking with Large Language Models](https://mlsanity.com/paper/2305.11483/) (2023)
- [RareBench: Can LLMs Serve as Rare Diseases Specialists?](https://mlsanity.com/paper/2402.06341/) (2024)
- [Multimodal Healthcare AI: Identifying and Designing Clinically Relevant Vision-Language Applications for Radiology](https://mlsanity.com/paper/2402.14252/) (2024)
- [CheXplain: Enabling Physicians to Explore and UnderstandData-Driven, AI-Enabled Medical Imaging Analysis](https://mlsanity.com/paper/2001.05149/) (2020)
- [WaitGPT: Monitoring and Steering Conversational LLM Agent in Data Analysis with On-the-Fly Code Visualization](https://mlsanity.com/paper/2408.01703/) (2024)
- [Ignore, Trust, or Negotiate: Understanding Clinician Acceptance of AI-Based Treatment Recommendations in Health Care](https://mlsanity.com/paper/2302.00096/) (2023)
- [Rethinking Human-AI Collaboration in Complex Medical Decision Making: A Case Study in Sepsis Diagnosis](https://mlsanity.com/paper/2309.12368/) (2023)
- ["Brilliant AI Doctor" in Rural China: Tensions and Challenges in AI-Powered CDSS Deployment](https://mlsanity.com/paper/2101.01524/) (2021)
- [AgentCoord: Visually Exploring Coordination Strategy for LLM-based Multi-Agent Collaboration](https://mlsanity.com/paper/2404.11943/) (2024)
- [AgentLens: Visual Analysis for Agent Behaviors in LLM-based Autonomous Systems](https://mlsanity.com/paper/2402.08995/) (2024)
- [Augmenting Pathologists with NaviPath: Design and Evaluation of a Human-AI Collaborative Navigation System](https://mlsanity.com/paper/2302.07309/) (2023)
- [MedKGI: Iterative Differential Diagnosis with Medical Knowledge Graphs and Information-Guided Inquiring](https://mlsanity.com/paper/2512.24181/) (2025)
- [DiLLS: Interactive Diagnosis of LLM-based Multi-agent Systems via Layered Summary of Agent Behaviors](https://mlsanity.com/paper/2602.05446/) (2026)
- [Design Patterns of Human-AI Interfaces in Healthcare](https://mlsanity.com/paper/2507.12721/) (2025)

## Abstract (arXiv)

Rare disease diagnosis is inherently challenging due to heterogeneous symptoms, limited clinical familiarity, and fragmented evidence across specialties. Recent large language model (LLM)-based agentic systems have shown promise by simulating multidisciplinary team discussions to generate and evaluate diagnostic hypotheses. However, fully automated diagnosis remains unrealistic, and existing human-in-the-loop approaches provide limited support for effective clinician-agent collaboration. In practice, clinicians are often presented with final diagnostic outputs and lengthy, unstructured agent discussion logs, making it difficult to inspect reasoning, intervene in a timely manner, or guide agent deliberation effectively. To address these challenges, we developed MDTRoom, an interactive system that transforms multi-agent discussions from linear transcripts into a structured, inspectable workspace. The system externalizes patient data, evidence provenance, hypothesis evolution, and inter-agent conflicts as interconnected visual objects, enabling clinicians to efficiently examine, intervene in, and guide agent reasoning. Our evaluation demonstrates the effectiveness of MDTRoom in supporting clinician-agent collaboration.