# From Foundation ECG Models to NISQ Learners: Distilling ECGFounder into a VQC Student

arXiv: https://arxiv.org/abs/2603.27269 · HTML: https://mlsanity.com/paper/2603.27269/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Distillation for medical imaging, one of 12 directions in Knowledge distillation.
- Builds on 15 of its 37 references that are in the map.
- First posted on arXiv 28 Mar 2026.

## Placed in

- Knowledge distillation / [Distillation for medical imaging](https://mlsanity.com/distill/distillation-for-medical-imaging/)

## Builds on (most cited first, 15 of 15)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [FitNets: Hints for Thin Deep Nets](https://mlsanity.com/paper/1412.6550/) (2014)
- [Knowledge Distillation: A Survey](https://mlsanity.com/paper/2006.05525/) (2020)
- [Paying More Attention to Attention: Improving the Performance of Convolutional Neural Networks via Attention Transfer](https://mlsanity.com/paper/1612.03928/) (2016)
- [Relational Knowledge Distillation](https://mlsanity.com/paper/1904.05068/) (2019)
- [Contrastive Representation Distillation](https://mlsanity.com/paper/1910.10699/) (2019)
- [Variational Quantum Algorithms](https://mlsanity.com/paper/2012.09265/) (2020)
- [Supervised learning with quantum enhanced feature spaces](https://mlsanity.com/paper/1804.11326/) (2018)
- [Improved Knowledge Distillation via Teacher Assistant](https://mlsanity.com/paper/1902.03393/) (2019)
- [Do Deep Nets Really Need to be Deep?](https://mlsanity.com/paper/1312.6184/) (2013)
- [Knowledge Distillation from A Stronger Teacher](https://mlsanity.com/paper/2205.10536/) (2022)
- [ECG-FM: An Open Electrocardiogram Foundation Model](https://mlsanity.com/paper/2408.05178/) (2024)
- [An Electrocardiogram Foundation Model Built on over 10 Million Recordings with External Evaluation across Multiple Domains](https://mlsanity.com/paper/2410.04133/) (2024)
- [Bridging Classical and Quantum Machine Learning: Knowledge Transfer From Classical to Quantum Neural Networks Using Knowledge Distillation](https://mlsanity.com/paper/2311.13810/) (2023)

## Abstract (arXiv)

Foundation models have recently improved electrocardiogram (ECG) representation learning, but their deployment can be limited by computational cost and latency constraints. In this work, we fine-tune ECGFounder as a high-capacity teacher for binary ECG classification on PTB-XL and the MIT-BIH Arrhythmia Database, and investigate whether knowledge distillation can transfer its predictive behavior to compact students. We evaluate two classical 1D students (ResNet-1D and a lightweight CNN-1D) and a quantum-ready pipeline that combines a convolutional autoencoder, which compresses 256-sample ECG windows into a low-dimensional latent representation, with a 6-qubit variational quantum circuit implemented in Qiskit and executed in a simulated backend. Across both datasets, the teacher provides the strongest overall performance, while distillation yields competitive students under a considerable reduction in trainable parameters. We further analyze the sensitivity of student performance to distillation settings, highlighting consistent accuracy--efficiency trade-offs when compressing a foundation ECG model into classical and quantum-ready learners under a unified evaluation protocol.