# Knowledge-Guided Retrieval-Augmented Generation for Zero-Shot Psychiatric Data: Privacy Preserving Synthetic Data Generation

arXiv: https://arxiv.org/abs/2603.25186 · HTML: https://mlsanity.com/paper/2603.25186/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 11 of its 38 references that are in the map.
- First posted on arXiv 26 Mar 2026.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)
- Synthetic data and self-improvement for LLMs / [Medical synthetic data and agents](https://mlsanity.com/synth/medical-synthetic-data-and-agents/)

## Builds on (most cited first, 11 of 11)

- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [Mistral 7B](https://mlsanity.com/paper/2310.06825/) (2023)
- [Deep Learning with Differential Privacy](https://mlsanity.com/paper/1607.00133/) (2016)
- [Extracting Training Data from Large Language Models](https://mlsanity.com/paper/2012.07805/) (2020)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Modeling Tabular data using Conditional GAN](https://mlsanity.com/paper/1907.00503/) (2019)
- [The Faiss library](https://mlsanity.com/paper/2401.08281/) (2024)
- [Real-valued (Medical) Time Series Generation with Recurrent Conditional GANs](https://mlsanity.com/paper/1706.02633/) (2017)
- [GatorTron: A Large Clinical Language Model to Unlock Patient Information from Unstructured Electronic Health Records](https://mlsanity.com/paper/2203.03540/) (2022)
- [Differentially Private Generative Adversarial Network](https://mlsanity.com/paper/1802.06739/) (2018)

## Abstract (arXiv)

AI systems in healthcare research have shown potential to increase patient throughput and assist clinicians, yet progress is constrained by limited access to real patient data. To address this issue, we present a zero-shot, knowledge-guided framework for psychiatric tabular data in which large language models (LLMs) are steered via Retrieval-Augmented Generation using the Diagnostic and Statistical Manual of Mental Disorders (DSM-5) and the International Classification of Diseases (ICD-10). We conducted experiments using different combinations of knowledge bases to generate privacy-preserving synthetic data. The resulting models were benchmarked against two state-of-the-art deep learning models for synthetic tabular data generation, namely CTGAN and TVAE, both of which rely on real data and therefore entail potential privacy risks. Evaluation was performed on six anxiety-related disorders: specific phobia, social anxiety disorder, agoraphobia, generalized anxiety disorder, separation anxiety disorder, and panic disorder. CTGAN typically achieves the best marginals and multivariate structure, while the knowledge-augmented LLM is competitive on pairwise structure and attains the lowest pairwise error in separation anxiety and social anxiety. An ablation study shows that clinical retrieval reliably improves univariate and pairwise fidelity over a no-retrieval LLM. Privacy analyses indicate that the real data-free LLM yields modest overlaps and a low average linkage risk comparable to CTGAN, whereas TVAE exhibits extensive duplication despite a low k-map score. Overall, grounding an LLM in clinical knowledge enables high-quality, privacy-preserving synthetic psychiatric data when real datasets are unavailable or cannot be shared.