# CARE: Training-Free Controllable Restoration for Medical Images via Dual-Latent Steering

arXiv: https://arxiv.org/abs/2603.25026 · HTML: https://mlsanity.com/paper/2603.25026/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 28 of its 42 references that are in the map.
- First posted on arXiv 26 Mar 2026.

## Builds on (most cited first, 28 of 28)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [The Unreasonable Effectiveness of Deep Features as a Perceptual Metric](https://mlsanity.com/paper/1801.03924/) (2018)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Denoising Diffusion Restoration Models](https://mlsanity.com/paper/2201.11793/) (2022)
- [Zero-Shot Image Restoration Using Denoising Diffusion Null-Space Model](https://mlsanity.com/paper/2212.00490/) (2022)
- [fastMRI: An Open Dataset and Benchmarks for Accelerated MRI](https://mlsanity.com/paper/1811.08839/) (2018)
- [Score-based diffusion models for accelerated MRI](https://mlsanity.com/paper/2110.05243/) (2021)
- [The Little Engine that Could: Regularization by Denoising (RED)](https://mlsanity.com/paper/1611.02862/) (2016)
- [FreeDoM: Training-Free Energy-Guided Conditional Diffusion Model](https://mlsanity.com/paper/2303.09833/) (2023)
- [Diffusion Models for Medical Image Analysis: A Comprehensive Survey](https://mlsanity.com/paper/2211.07804/) (2022)
- [Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network (RED-CNN)](https://mlsanity.com/paper/1702.00288/) (2017)
- [End-to-End Variational Networks for Accelerated MRI Reconstruction](https://mlsanity.com/paper/2004.06688/) (2020)
- [A Survey on Diffusion Models for Inverse Problems](https://mlsanity.com/paper/2410.00083/) (2024)
- [Low Dose CT Image Denoising Using a Generative Adversarial Network with Wasserstein Distance and Perceptual Loss](https://mlsanity.com/paper/1708.00961/) (2017)
- [Solving 3D Inverse Problems using Pre-trained 2D Diffusion Models](https://mlsanity.com/paper/2211.10655/) (2022)
- [Bayesian MRI Reconstruction with Joint Uncertainty Estimation using Diffusion Models](https://mlsanity.com/paper/2202.01479/) (2022)
- [CTformer: Convolution-free Token2Token Dilated Vision Transformer for Low-dose CT Denoising](https://mlsanity.com/paper/2202.13517/) (2022)
- [Quadratic Autoencoder (Q-AE) for Low-dose CT Denoising](https://mlsanity.com/paper/1901.05593/) (2019)
- [EDCNN: Edge enhancement-based Densely Connected Network with Compound Loss for Low-Dose CT Denoising](https://mlsanity.com/paper/2011.00139/) (2020)
- [XPDNet for MRI Reconstruction: an application to the 2020 fastMRI challenge](https://mlsanity.com/paper/2010.07290/) (2020)
- [Tackling Hallucination from Conditional Models for Medical Image Reconstruction with DynamicDPS](https://mlsanity.com/paper/2503.01075/) (2025)
- [Training-Free Multi-Style Fusion Through Reference-Based Adaptive Modulation](https://mlsanity.com/paper/2509.18602/) (2025)
- [Prompt-Guided Dual Latent Steering for Inversion Problems](https://mlsanity.com/paper/2509.18619/) (2025)
- [DiffDenoise: Self-Supervised Medical Image Denoising with Conditional Diffusion Models](https://mlsanity.com/paper/2504.00264/) (2025)

## Abstract (arXiv)

Medical image restoration is essential for improving the usability of noisy, incomplete, and artifact-corrupted clinical scans, yet existing methods often rely on task-specific retraining and offer limited control over the trade-off between faithful reconstruction and prior-driven enhancement. This lack of controllability is especially problematic in clinical settings, where overly aggressive restoration may introduce hallucinated details or alter diagnostically important structures. In this work, we propose CARE, a training-free controllable restoration framework for real-world medical images that explicitly balances structure preservation and prior-guided refinement during inference. CARE uses a dual-latent restoration strategy, in which one branch enforces data fidelity and anatomical consistency while the other leverages a generative prior to recover missing or degraded information. A risk-aware adaptive controller dynamically adjusts the contribution of each branch based on restoration uncertainty and local structural reliability, enabling conservative or enhancement-focused restoration modes without additional model training. We evaluate CARE on noisy and incomplete medical imaging scenarios and show that it achieves strong restoration quality while better preserving clinically relevant structures and reducing the risk of implausible reconstructions and show that it achieves strong restoration quality while better preserving clinically relevant structures and reducing the risk of implausible reconstructions. The proposed approach offers a practical step toward safer, more controllable, and more deployment-ready medical image restoration.