# ReconMIL: Synergizing Latent Space Reconstruction with Bi-Stream Mamba for Whole Slide Image Analysis

arXiv: https://arxiv.org/abs/2603.19925 · HTML: https://mlsanity.com/paper/2603.19925/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 107 of its 143 references that are in the map.
- First posted on arXiv 20 Mar 2026.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 30 of 107)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [A Survey on Deep Learning in Medical Image Analysis](https://mlsanity.com/paper/1702.05747/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [Data Efficient and Weakly Supervised Computational Pathology on Whole Slide Images](https://mlsanity.com/paper/2004.09666/) (2020)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Dual-stream Multiple Instance Learning Network for Whole Slide Image Classification with Self-supervised Contrastive Learning](https://mlsanity.com/paper/2011.08939/) (2020)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [Scaling Vision Transformers to Gigapixel Images via Hierarchical Self-Supervised Learning](https://mlsanity.com/paper/2206.02647/) (2022)
- [MACE: Mass Concept Erasure in Diffusion Models](https://mlsanity.com/paper/2403.06135/) (2024)
- [DTFD-MIL: Double-Tier Feature Distillation Multiple Instance Learning for Histopathology Whole Slide Image Classification](https://mlsanity.com/paper/2203.12081/) (2022)
- [TF-ICON: Diffusion-Based Training-Free Cross-Domain Image Composition](https://mlsanity.com/paper/2307.12493/) (2023)
- [Quantifying the effects of data augmentation and stain color normalization in convolutional neural networks for computational pathology](https://mlsanity.com/paper/1902.06543/) (2019)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Multimodal Whole Slide Foundation Model for Pathology](https://mlsanity.com/paper/2411.19666/) (2024)
- [HunyuanVideo 1.5 Technical Report](https://mlsanity.com/paper/2511.18870/) (2025)
- [BRACS: A Dataset for BReAst Carcinoma Subtyping in H&E Histology Images](https://mlsanity.com/paper/2111.04740/) (2021)
- [ODTrack: Online Dense Temporal Token Learning for Visual Tracking](https://mlsanity.com/paper/2401.01686/) (2024)
- [Robust Watermarking Using Generative Priors Against Image Editing: From Benchmarking to Advances](https://mlsanity.com/paper/2410.18775/) (2024)
- [EraseAnything: Enabling Concept Erasure in Rectified Flow Transformers](https://mlsanity.com/paper/2412.20413/) (2024)
- [Interventional Bag Multi-Instance Learning On Whole-Slide Pathological Images](https://mlsanity.com/paper/2303.06873/) (2023)
- [MedMamba: Vision Mamba for Medical Image Classification](https://mlsanity.com/paper/2403.03849/) (2024)
- [MambaMIL: Enhancing Long Sequence Modeling with Sequence Reordering in Computational Pathology](https://mlsanity.com/paper/2403.06800/) (2024)
- [Feature Re-Embedding: Towards Foundation Model-Level Performance in Computational Pathology](https://mlsanity.com/paper/2402.17228/) (2024)
- [UltraPixel: Advancing Ultra-High-Resolution Image Synthesis to New Peaks](https://mlsanity.com/paper/2407.02158/) (2024)
- [Structure-Preserving Deraining with Residue Channel Prior Guidance](https://mlsanity.com/paper/2108.09079/) (2021)
- [Towards Unified Token Learning for Vision-Language Tracking](https://mlsanity.com/paper/2308.14103/) (2023)
- [Set You Straight: Auto-Steering Denoising Trajectories to Sidestep Unwanted Concepts](https://mlsanity.com/paper/2504.12782/) (2025)
- [Multiple Instance Learning Framework with Masked Hard Instance Mining for Whole Slide Image Classification](https://mlsanity.com/paper/2307.15254/) (2023)
- [The Ninth NTIRE 2024 Efficient Super-Resolution Challenge Report](https://mlsanity.com/paper/2404.10343/) (2024)

## Abstract (arXiv)

Whole slide image (WSI) analysis heavily relies on multiple instance learning (MIL). While recent methods benefit from large-scale foundation models and advanced sequence modeling to capture long-range dependencies, they still struggle with two critical issues. First, directly applying frozen, task-agnostic features often leads to suboptimal separability due to the domain gap with specific histological tasks. Second, relying solely on global aggregators can cause over-smoothing, where sparse but critical diagnostic signals are overshadowed by the dominant background context. In this paper, we present ReconMIL, a novel framework designed to bridge this domain gap and balance global-local feature aggregation. Our approach introduces a Latent Space Reconstruction module that adaptively projects generic features into a compact, task-specific manifold, improving boundary delineation. To prevent information dilution, we develop a bi-stream architecture combining a Mamba-based global stream for contextual priors and a CNN-based local stream to preserve subtle morphological anomalies. A scale-adaptive selection mechanism dynamically fuses these two streams, determining when to rely on overall architecture versus local saliency. Evaluations across multiple diagnostic and survival prediction benchmarks show that ReconMIL consistently outperforms current state-of-the-art methods, effectively localizing fine-grained diagnostic regions while suppressing background noise. Visualization results confirm the models superior ability to localize diagnostic regions by effectively balancing global structure and local granularity.