# PRIME-CVD: A Parametrically Rendered Informatics Medical Environment for Education in Cardiovascular Risk Modelling

arXiv: https://arxiv.org/abs/2603.19299 · HTML: https://mlsanity.com/paper/2603.19299/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 7 of its 55 references that are in the map.
- First posted on arXiv 11 Mar 2026.

## Builds on (most cited first, 7 of 7)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [The Secret Revealer: Generative Model-Inversion Attacks Against Deep Neural Networks](https://mlsanity.com/paper/1911.07135/) (2019)
- [The Health Gym: Synthetic Health-Related Datasets for the Development of Reinforcement Learning Algorithms](https://mlsanity.com/paper/2203.06369/) (2022)
- [Synthetic Health-related Longitudinal Data with Mixed-type Variables Generated using Diffusion Models](https://mlsanity.com/paper/2303.12281/) (2023)
- [De-identifying Australian Hospital Discharge Summaries: An End-to-End Framework using Ensemble of Deep Learning Models](https://mlsanity.com/paper/2101.00146/) (2021)
- [Limits of Generative Pre-Training in Structured EMR Trajectories with Irregular Sampling](https://mlsanity.com/paper/2510.22878/) (2025)

## Built on by (most cited first, 1 of 1)

- [Synthetic but Not Realistic: The Evaluation Challenge in Generative Modelling for Structured Electronic Medical Records](https://mlsanity.com/paper/2606.08903/) (2026)

## Abstract (arXiv)

In recent years, progress in medical informatics and machine learning has been accelerated by the availability of openly accessible benchmark datasets. However, patient-level electronic medical record (EMR) data are rarely available for teaching or methodological development due to privacy, governance, and re-identification risks. This has limited reproducibility, transparency, and hands-on training in cardiovascular risk modelling. Here we introduce PRIME-CVD, a parametrically rendered informatics medical environment designed explicitly for medical education. PRIME-CVD comprises two openly accessible synthetic data assets representing a cohort of 50,000 adults undergoing primary prevention for cardiovascular disease. The datasets are generated entirely from a user-specified causal directed acyclic graph parameterised using publicly available Australian population statistics and published epidemiologic effect estimates, rather than from patient-level EMR data or trained generative models. Data Asset 1 provides a clean, analysis-ready cohort suitable for exploratory analysis, stratification, and survival modelling, while Data Asset 2 restructures the same cohort into a relational, EMR-style database with realistic structural and lexical heterogeneity. Together, these assets enable instruction in data cleaning, harmonisation, causal reasoning, and policy-relevant risk modelling without exposing sensitive information. Because all individuals and events are generated de novo, PRIME-CVD preserves realistic subgroup imbalance and risk gradients while ensuring negligible disclosure risk. PRIME-CVD is released under a Creative Commons Attribution 4.0 licence to support reproducible research and scalable medical education.