# LGESynthNet: Controlled Scar Synthesis for Improved Scar Segmentation in Cardiac LGE-MRI Imaging

arXiv: https://arxiv.org/abs/2603.18356 · HTML: https://mlsanity.com/paper/2603.18356/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 19 of its 28 references that are in the map.
- First posted on arXiv 18 Mar 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 19 of 19)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [T2I-Adapter: Learning Adapters to Dig out More Controllable Ability for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.08453/) (2023)
- [Semantic Image Synthesis with Spatially-Adaptive Normalization](https://mlsanity.com/paper/1903.07291/) (2019)
- [Diffusion Models for Medical Image Analysis: A Comprehensive Survey](https://mlsanity.com/paper/2211.07804/) (2022)
- [Generative Adversarial Network in Medical Imaging: A Review](https://mlsanity.com/paper/1809.07294/) (2018)
- [ControlNet++: Improving Conditional Controls with Efficient Consistency Feedback](https://mlsanity.com/paper/2404.07987/) (2024)
- [Diffusion Probabilistic Models beat GANs on Medical Images](https://mlsanity.com/paper/2212.07501/) (2022)
- [Adaptive Latent Diffusion Model for 3D Medical Image to Image Translation: Multi-modal Magnetic Resonance Imaging Study](https://mlsanity.com/paper/2311.00265/) (2023)
- [ControlNet-XS: Rethinking the Control of Text-to-Image Diffusion Models as Feedback-Control Systems](https://mlsanity.com/paper/2312.06573/) (2023)
- [VTGAN: Semi-supervised Retinal Image Synthesis and Disease Prediction using Vision Transformers](https://mlsanity.com/paper/2104.06757/) (2021)
- [Deep Learning methods for automatic evaluation of delayed enhancement-MRI. The results of the EMIDEC challenge](https://mlsanity.com/paper/2108.04016/) (2021)
- [Synthetic optical coherence tomography angiographs for detailed retinal vessel segmentation without human annotations](https://mlsanity.com/paper/2306.10941/) (2023)
- [Cascaded Convolutional Neural Network for Automatic Myocardial Infarction Segmentation from Delayed-Enhancement Cardiac MRI](https://mlsanity.com/paper/2012.14128/) (2020)
- [CLAIM: Clinically-Guided LGE Augmentation for Realistic and Diverse Myocardial Scar Synthesis and Segmentation](https://mlsanity.com/paper/2506.15549/) (2025)
- [Fake It Till You Make It: Using Synthetic Data and Domain Knowledge for Improved Text-Based Learning for LGE Detection](https://mlsanity.com/paper/2502.12948/) (2025)

## Abstract (arXiv)

Segmentation of enhancement in LGE cardiac MRI is critical for diagnosing various ischemic and non-ischemic cardiomyopathies. However, creating pixel-level annotations for these images is challenging and labor-intensive, leading to limited availability of annotated data. Generative models, particularly diffusion models, offer promise for synthetic data generation, yet many rely on large training datasets and often struggle with fine-grained conditioning control, especially for small or localized features. We introduce LGESynthNet, a latent diffusion-based framework for controllable enhancement synthesis, enabling explicit control over size, location, and transmural extent. Formulated as inpainting using a ControlNet-based architecture, the model integrates: (a) a reward model for conditioning-specific supervision, (b) a captioning module for anatomically descriptive text prompts, and (c) a biomedical text encoder. Trained on just 429 images (79 patients), it produces realistic, anatomically coherent samples. A quality control filter selects outputs with high conditioning-fidelity, which when used for training augmentation, improve downstream segmentation and detection performance, by up-to 6 and 20 points respectively.