# OpenQlaw: An Agentic AI Assistant for Analysis of 2D Quantum Materials

arXiv: https://arxiv.org/abs/2603.17043 · HTML: https://mlsanity.com/paper/2603.17043/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Clinical and biomedical applications, one of 17 directions in LLM reasoning.
- Builds on 29 of its 42 references that are in the map.
- First posted on arXiv 17 Mar 2026.

## Placed in

- LLM reasoning / [Clinical and biomedical applications](https://mlsanity.com/lr/clinical-and-biomedical-applications/)
- LLM agents and tool use / [Medical and scientific domain agents](https://mlsanity.com/agents/medical-and-scientific-domain-agents/)

## Builds on (most cited first, 29 of 29)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Qwen3 Technical Report](https://mlsanity.com/paper/2505.09388/) (2025)
- [Segment Anything](https://mlsanity.com/paper/2304.02643/) (2023)
- [End-to-End Object Detection with Transformers](https://mlsanity.com/paper/2005.12872/) (2020)
- [You Only Look Once: Unified, Real-Time Object Detection](https://mlsanity.com/paper/1506.02640/) (2015)
- [Deformable DETR: Deformable Transformers for End-to-End Object Detection](https://mlsanity.com/paper/2010.04159/) (2020)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [BiMaL: Bijective Maximum Likelihood Approach to Domain Adaptation in Semantic Scene Segmentation](https://mlsanity.com/paper/2108.03267/) (2021)
- [FREDOM: Fairness Domain Adaptation Approach to Semantic Scene Understanding](https://mlsanity.com/paper/2304.02135/) (2023)
- [Deep-Learning-Based Image Segmentation Integrated with Optical Microscopy for Automatically Searching for Two-Dimensional Materials](https://mlsanity.com/paper/1910.12750/) (2019)
- [Fairness Continual Learning Approach to Semantic Scene Understanding in Open-World Environments](https://mlsanity.com/paper/2305.15700/) (2023)
- [Two-Dimensional Quantum Material Identification via Self-Attention and Soft-labeling in Deep Learning](https://mlsanity.com/paper/2205.15948/) (2022)
- [Quantum Vision Clustering](https://mlsanity.com/paper/2309.09907/) (2023)
- [FALCON: Fairness Learning via Contrastive Attention Approach to Continual Semantic Scene Understanding](https://mlsanity.com/paper/2311.15965/) (2023)
- [OTAdapt: Optimal Transport-based Approach For Unsupervised Domain Adaptation](https://mlsanity.com/paper/2205.10738/) (2022)
- [Self-supervised Domain Adaptation in Crowd Counting](https://mlsanity.com/paper/2206.03431/) (2022)
- [CONDA: Continual Unsupervised Domain Adaptation Learning in Visual Perception for Self-Driving Cars](https://mlsanity.com/paper/2212.00621/) (2022)
- [Quantum Visual Feature Encoding Revisited](https://mlsanity.com/paper/2405.19725/) (2024)
- [Diffusion-Inspired Quantum Noise Mitigation in Parameterized Quantum Circuits](https://mlsanity.com/paper/2406.00843/) (2024)
- [Defining Quantum Neural Networks via Quantum Time Evolution](https://mlsanity.com/paper/1905.10912/) (2019)
- [Hierarchical Quantum Control Gates for Functional MRI Understanding](https://mlsanity.com/paper/2408.03596/) (2024)
- [Quantum-Brain: Quantum-Inspired Neural Network Approach to Vision-Brain Understanding](https://mlsanity.com/paper/2411.13378/) (2024)
- [QMoE: A Quantum Mixture of Experts Framework for Scalable Quantum Neural Networks](https://mlsanity.com/paper/2507.05190/) (2025)
- [EAGLE: Efficient Adaptive Geometry-based Learning in Cross-view Understanding](https://mlsanity.com/paper/2406.01429/) (2024)
- [MaskTerial: A Foundation Model for Automated 2D Material Flake Detection](https://mlsanity.com/paper/2412.09333/) (2024)
- [varphi-Adapt: A Physics-Informed Adaptation Learning Approach to 2D Quantum Material Discovery](https://mlsanity.com/paper/2507.05184/) (2025)
- [QuPAINT: Physics-Aware Instruction Tuning Approach to Quantum Material Discovery](https://mlsanity.com/paper/2602.17478/) (2026)
- [CLIFF: Continual Learning for Incremental Flake Features in 2D Material Identification](https://mlsanity.com/paper/2508.17261/) (2025)
- [φ-DPO: Fairness Direct Preference Optimization Approach to Continual Learning in Large Multimodal Models](https://mlsanity.com/paper/2602.22601/) (2026)

## Built on by (most cited first, 1 of 1)

- [QLAM: A Quantum Long-Attention Memory Approach to Long-Sequence Token Modeling](https://mlsanity.com/paper/2605.13833/) (2026)

## Abstract (arXiv)

Physics-aware multimodal large language models (MLLMs) can localize and characterize two-dimensional (2D) material flakes from optical microscopy images, producing rich candidate observations and scientific reasoning. However, downstream workflows also require reliable operations over these outputs, including counting, selection, measurement, and rendering. We present OpenQlaw, a tool-using agentic artificial intelligence (AI) system that connects a general vision-language orchestrator with Physics-Aware Instruction Tuning (QuPAINT), a physics-aware domain expert. Through evaluation on fully reviewed optical microscopy images, we show that summary counts derived from longer free-form candidate enumerations can become inconsistent with the underlying returned observations. Controlled replay experiments further show that structuring the same observations alone does not resolve this behavior, while deterministic delegation returns the exact requested record count in all cohort trials. To address this, we introduce State-Grounded OpenQlaw, which converts expert outputs into image-scoped observation records and performs deterministic scientific operations over explicitly identified records with refusal conditions when required information is unavailable. This preserves the expert's original analysis while making downstream operations exact over the selected record and independently evaluable from candidate-list discrepancies.