# Self-Supervised ImageNet Representations for In Vivo Confocal Microscopy: Tortuosity Grading without Segmentation Maps

arXiv: https://arxiv.org/abs/2603.15269 · HTML: https://mlsanity.com/paper/2603.15269/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 3 of its 9 references that are in the map.
- First posted on arXiv 16 Mar 2026.

## Builds on (most cited first, 3 of 3)

- [ImageNet Large Scale Visual Recognition Challenge](https://mlsanity.com/paper/1409.0575/) (2014)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)

## Abstract (arXiv)

The tortuosity of corneal nerve fibers are used as indication for different diseases. Current state-of-the-art methods for grading the tortuosity heavily rely on expensive segmentation maps of these nerve fibers. In this paper, we demonstrate that self-supervised pretrained features from ImageNet are transferable to the domain of in vivo confocal microscopy. We show that DINO should not be disregarded as a deep learning model for medical imaging, although it was superseded by two later versions. After careful fine-tuning, DINO improves upon the state-of-the-art in terms of accuracy (84,25%) and sensitivity (77,97%). Our fine-tuned model focuses on the key morphological elements in grading without the use of segmentation maps.