# Learning from Limited and Incomplete Data: A Multimodal Framework for Predicting Pathological Response in NSCLC

arXiv: https://arxiv.org/abs/2603.15100 · HTML: https://mlsanity.com/paper/2603.15100/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 6 of its 16 references that are in the map.
- First posted on arXiv 16 Mar 2026.

## Builds on (most cited first, 6 of 6)

- [On the Challenges and Perspectives of Foundation Models for Medical Image Analysis](https://mlsanity.com/paper/2306.05705/) (2023)
- [A Systematic Review of Intermediate Fusion in Multimodal Deep Learning for Biomedical Applications](https://mlsanity.com/paper/2408.02686/) (2024)
- [Not Another Imputation Method: A Transformer-based Model for Missing Values in Tabular Datasets](https://mlsanity.com/paper/2407.11540/) (2024)
- [Doctor-in-the-Loop: An Explainable, Multi-View Deep Learning Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer](https://mlsanity.com/paper/2502.17503/) (2025)
- [MARIA: a Multimodal Transformer Model for Incomplete Healthcare Data](https://mlsanity.com/paper/2412.14810/) (2024)
- [Multimodal Doctor-in-the-Loop: A Clinically-Guided Explainable Framework for Predicting Pathological Response in Non-Small Cell Lung Cancer](https://mlsanity.com/paper/2505.01390/) (2025)

## Abstract (arXiv)

Major pathological response (pR) following neoadjuvant therapy is a clinically meaningful endpoint in non-small cell lung cancer, strongly associated with improved survival. However, accurate preoperative prediction of pR remains challenging, particularly in real-world clinical settings characterized by limited data availability and incomplete clinical profiles. In this study, we propose a multimodal deep learning framework designed to address these constraints by integrating foundation model-based CT feature extraction with a missing-aware architecture for clinical variables. This approach enables robust learning from small cohorts while explicitly modeling missing clinical information, without relying on conventional imputation strategies. A weighted fusion mechanism is employed to leverage the complementary contributions of imaging and clinical modalities, yielding a multimodal model that consistently outperforms both unimodal imaging and clinical baselines. These findings underscore the added value of integrating heterogeneous data sources and highlight the potential of multimodal, missing-aware systems to support pR prediction under realistic clinical conditions.