# D-MEM: Dopamine-Gated Agentic Memory via Reward Prediction Error Routing

arXiv: https://arxiv.org/abs/2603.14597 · HTML: https://mlsanity.com/paper/2603.14597/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Agent memory systems, one of 16 directions in LLM agents and tool use.
- Builds on 22 of its 27 references that are in the map.
- First posted on arXiv 15 Mar 2026.

## Placed in

- LLM agents and tool use / [Agent memory systems](https://mlsanity.com/agents/agent-memory-systems/)

## Builds on (most cited first, 22 of 22)

- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Dense Passage Retrieval for Open-Domain Question Answering](https://mlsanity.com/paper/2004.04906/) (2020)
- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [Outrageously Large Neural Networks: The Sparsely-Gated Mixture-of-Experts Layer](https://mlsanity.com/paper/1701.06538/) (2017)
- [Lost in the Middle: How Language Models Use Long Contexts](https://mlsanity.com/paper/2307.03172/) (2023)
- [Tree of Thoughts: Deliberate Problem Solving with Large Language Models](https://mlsanity.com/paper/2305.10601/) (2023)
- [A Survey on Large Language Model based Autonomous Agents](https://mlsanity.com/paper/2308.11432/) (2023)
- [Retrieval-Augmented Generation for Large Language Models: A Survey](https://mlsanity.com/paper/2312.10997/) (2023)
- [The Rise and Potential of Large Language Model Based Agents: A Survey](https://mlsanity.com/paper/2309.07864/) (2023)
- [LongBench: A Bilingual, Multitask Benchmark for Long Context Understanding](https://mlsanity.com/paper/2308.14508/) (2023)
- [MemGPT: Towards LLMs as Operating Systems](https://mlsanity.com/paper/2310.08560/) (2023)
- [A-MEM: Agentic Memory for LLM Agents](https://mlsanity.com/paper/2502.12110/) (2025)
- [FrugalGPT: How to Use Large Language Models While Reducing Cost and Improving Performance](https://mlsanity.com/paper/2305.05176/) (2023)
- [Evaluating Very Long-Term Conversational Memory of LLM Agents](https://mlsanity.com/paper/2402.17753/) (2024)
- [A Survey on the Memory Mechanism of Large Language Model based Agents](https://mlsanity.com/paper/2404.13501/) (2024)
- [MemoryBank: Enhancing Large Language Models with Long-Term Memory](https://mlsanity.com/paper/2305.10250/) (2023)
- [Adaptive Computation Time for Recurrent Neural Networks](https://mlsanity.com/paper/1603.08983/) (2016)
- [Confident Adaptive Language Modeling](https://mlsanity.com/paper/2207.07061/) (2022)
- [L-Eval: Instituting Standardized Evaluation for Long Context Language Models](https://mlsanity.com/paper/2307.11088/) (2023)
- [Augmenting Language Models with Long-Term Memory](https://mlsanity.com/paper/2306.07174/) (2023)
- [RET-LLM: Towards a General Read-Write Memory for Large Language Models](https://mlsanity.com/paper/2305.14322/) (2023)

## Built on by (most cited first, 1 of 1)

- [MemoWM: How World Models Change What Agents Need to Remember](https://mlsanity.com/paper/2610.10778/) (2026)

## Abstract (arXiv)

Autonomous LLM agents require structured long-term memory, yet current "append-and-evolve" systems like A-MEM face O(N^2) write-latency and excessive token costs. We introduce D-MEM (Dopamine-Gated Agentic Memory), a biologically inspired architecture that decouples short-term interaction from cognitive restructuring via a Fast/Slow routing system based on Reward Prediction Error (RPE). A lightweight Critic Router evaluates stimuli for Surprise and Utility. Routine, low-RPE inputs are bypassed or cached in an O(1) fast-access buffer. Conversely, high-RPE inputs, such as factual contradictions or preference shifts, trigger a "dopamine" signal, activating the O(N) memory evolution pipeline to reshape the agent's knowledge graph. To evaluate performance under realistic conditions, we introduce the LoCoMo-Noise benchmark, which injects controlled conversational noise into long-term sessions. Evaluations demonstrate that D-MEM reduces token consumption by over 80%, eliminates O(N^2) bottlenecks, and outperforms baselines in multi-hop reasoning and adversarial resilience. By selectively gating cognitive restructuring, D-MEM provides a scalable, cost-efficient foundation for lifelong agentic memory.