# Trust-Region Noise Search for Black-Box Alignment of Diffusion and Flow Models

arXiv: https://arxiv.org/abs/2603.14504 · HTML: https://mlsanity.com/paper/2603.14504/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Diffusion and multimodal model alignment, one of 10 directions in LLM alignment / RLHF / preference optimisation.
- Builds on 31 of its 48 references that are in the map.
- First posted on arXiv 15 Mar 2026.

## Placed in

- LLM alignment / RLHF / preference optimisation / [Diffusion and multimodal model alignment](https://mlsanity.com/alignment/diffusion-and-multimodal-model-alignment/)

## Builds on (most cited first, 30 of 31)

- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Photorealistic Text-to-Image Diffusion Models with Deep Language Understanding](https://mlsanity.com/paper/2205.11487/) (2022)
- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [LAION-5B: An open large-scale dataset for training next generation image-text models](https://mlsanity.com/paper/2210.08402/) (2022)
- [Flow Straight and Fast: Learning to Generate and Transfer Data with Rectified Flow](https://mlsanity.com/paper/2209.03003/) (2022)
- [ImageReward: Learning and Evaluating Human Preferences for Text-to-Image Generation](https://mlsanity.com/paper/2304.05977/) (2023)
- [Training Diffusion Models with Reinforcement Learning](https://mlsanity.com/paper/2305.13301/) (2023)
- [Human Preference Score v2: A Solid Benchmark for Evaluating Human Preferences of Text-to-Image Synthesis](https://mlsanity.com/paper/2306.09341/) (2023)
- [Equivariant Diffusion for Molecule Generation in 3D](https://mlsanity.com/paper/2203.17003/) (2022)
- [GeoDiff: a Geometric Diffusion Model for Molecular Conformation Generation](https://mlsanity.com/paper/2203.02923/) (2022)
- [Directly Fine-Tuning Diffusion Models on Differentiable Rewards](https://mlsanity.com/paper/2309.17400/) (2023)
- [Universal Guidance for Diffusion Models](https://mlsanity.com/paper/2302.07121/) (2023)
- [Scalable Global Optimization via Local Bayesian Optimization](https://mlsanity.com/paper/1910.01739/) (2019)
- [A General Framework for Inference-time Scaling and Steering of Diffusion Models](https://mlsanity.com/paper/2501.06848/) (2025)
- [3D Equivariant Diffusion for Target-Aware Molecule Generation and Affinity Prediction](https://mlsanity.com/paper/2303.03543/) (2023)
- [SE(3)-Stochastic Flow Matching for Protein Backbone Generation](https://mlsanity.com/paper/2310.02391/) (2023)
- [Derivative-Free Guidance in Continuous and Discrete Diffusion Models with Soft Value-Based Decoding](https://mlsanity.com/paper/2408.08252/) (2024)
- [InitNO: Boosting Text-to-Image Diffusion Models via Initial Noise Optimization](https://mlsanity.com/paper/2404.04650/) (2024)
- [D-Flow: Differentiating through Flows for Controlled Generation](https://mlsanity.com/paper/2402.14017/) (2024)
- [ReNO: Enhancing One-step Text-to-Image Models through Reward-based Noise Optimization](https://mlsanity.com/paper/2406.04312/) (2024)
- [Test-time Alignment of Diffusion Models without Reward Over-optimization](https://mlsanity.com/paper/2501.05803/) (2025)
- [Proteina: Scaling Flow-based Protein Structure Generative Models](https://mlsanity.com/paper/2503.00710/) (2025)
- [Inference-Time Alignment of Diffusion Models with Direct Noise Optimization](https://mlsanity.com/paper/2405.18881/) (2024)
- [Dynamic Search for Inference-Time Alignment in Diffusion Models](https://mlsanity.com/paper/2503.02039/) (2025)
- [Diffusion Tree Sampling: Scalable inference-time alignment of diffusion models](https://mlsanity.com/paper/2506.20701/) (2025)
- [Training Free Guided Flow Matching with Optimal Control](https://mlsanity.com/paper/2410.18070/) (2024)

## Abstract (arXiv)

Optimizing the noise samples of diffusion and flow models is an increasingly popular approach to align these models to target rewards at inference time. However, we observe that these approaches are usually restricted to differentiable or cheap reward models, the formulation of the underlying pretrained generative model, or are memory/compute inefficient. We instead propose a simple trust-region based search algorithm (TRS) which treats the pre-trained generative and reward models as a black-box and only optimizes the source noise. Our approach achieves a good balance between global exploration and local exploitation, and is versatile and easily adaptable to various generative settings and reward models with minimal hyperparameter tuning. We evaluate TRS across text-to-image, molecule and protein design tasks, and obtain significantly improved output samples over the base generative models and other inference-time alignment approaches which optimize the source noise sample, or even the entire reverse-time sampling noise trajectories in the case of diffusion models. Our source code is publicly available.