# Deep probabilistic model synthesis enables unified modeling of whole-brain neural activity across individual subjects

arXiv: https://arxiv.org/abs/2603.14161 · HTML: https://mlsanity.com/paper/2603.14161/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 19 of its 67 references that are in the map.
- First posted on arXiv 15 Mar 2026.

## Builds on (most cited first, 19 of 19)

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## Abstract (arXiv)

Many disciplines need quantitative models that synthesize experimental data across multiple instances of the same general system. For example, neuroscientists must combine data from the brains of many individual animals to understand the species' brain in general. However, typical machine learning models treat one system instance at a time. Here we introduce a machine learning framework, deep probabilistic model synthesis (DPMS), that leverages system properties auxiliary to the model to combine data across system instances. DPMS specifically uses variational inference to learn a conditional prior distribution and instance-specific posterior distributions over model parameters that respectively tie together the system instances and capture their unique structure. DPMS can synthesize a wide variety of model classes, such as those for regression, classification, and dimensionality reduction, and we demonstrate its ability to improve upon single-instance models on synthetic data and whole-brain neural activity data from larval zebrafish.