# QuarkMedBench: A Real-World Scenario Driven Benchmark for Evaluating Large Language Models

arXiv: https://arxiv.org/abs/2603.13691 · HTML: https://mlsanity.com/paper/2603.13691/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 16 of its 47 references that are in the map.
- First posted on arXiv 14 Mar 2026.

## Builds on (most cited first, 16 of 16)

- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [Siren's Song in the AI Ocean: A Survey on Hallucination in Large Language Models](https://mlsanity.com/paper/2309.01219/) (2023)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [MedMCQA : A Large-scale Multi-Subject Multi-Choice Dataset for Medical domain Question Answering](https://mlsanity.com/paper/2203.14371/) (2022)
- [HealthBench: Evaluating Large Language Models Towards Improved Human Health](https://mlsanity.com/paper/2505.08775/) (2025)
- [Rubrics as Rewards: Reinforcement Learning Beyond Verifiable Domains](https://mlsanity.com/paper/2507.17746/) (2025)
- [A Survey of Large Language Models for Healthcare: from Data, Technology, and Applications to Accountability and Ethics](https://mlsanity.com/paper/2310.05694/) (2023)
- [Reinforcement Learning with Rubric Anchors](https://mlsanity.com/paper/2508.12790/) (2025)
- [Explaining Length Bias in LLM-Based Preference Evaluations](https://mlsanity.com/paper/2407.01085/) (2024)
- [Self-Evolving Multi-Agent Simulations for Realistic Clinical Interactions](https://mlsanity.com/paper/2503.22678/) (2025)
- [Shallow Robustness, Deep Vulnerabilities: Multi-Turn Evaluation of Medical LLMs](https://mlsanity.com/paper/2510.12255/) (2025)
- [QuarkMed Medical Foundation Model Technical Report](https://mlsanity.com/paper/2508.11894/) (2025)
- [Quark Medical Alignment: A Holistic Multi-Dimensional Alignment and Collaborative Optimization Paradigm](https://mlsanity.com/paper/2602.11661/) (2026)
- [The Biased Oracle: Assessing LLMs' Understandability and Empathy in Medical Diagnoses](https://mlsanity.com/paper/2511.00924/) (2025)

## Built on by (most cited first, 1 of 1)

- [QuarkMedSearch: A Long-Horizon Deep Search Agent for Exploring Medical Intelligence](https://mlsanity.com/paper/2604.12867/) (2026)

## Abstract (arXiv)

While Large Language Models (LLMs) excel on standardized medical exams, high scores often fail to translate to high-quality responses for real-world medical queries. Current evaluations rely heavily on multiple-choice questions, failing to capture the unstructured, ambiguous, and long-tail complexities inherent in genuine user inquiries. To bridge this gap, we introduce QuarkMedBench, an ecologically valid benchmark tailored for real-world medical LLM assessment. We compiled a massive dataset spanning Clinical Care, Wellness Health, and Professional Inquiry, comprising 20,821 single-turn queries and 3,853 multi-turn sessions. To objectively evaluate open-ended answers, we propose an automated scoring framework that integrates multi-model consensus with evidence-based retrieval to dynamically generate 220,617 fine-grained scoring rubrics (~9.8 per query). During evaluation, hierarchical weighting and safety constraints structurally quantify medical accuracy, key-point coverage, and risk interception, effectively mitigating the high costs and subjectivity of human grading. Experimental results demonstrate that the generated rubrics achieve a 91.8% concordance rate with clinical expert blind audits, establishing highly dependable medical reliability. Crucially, baseline evaluations on this benchmark reveal significant performance disparities among state-of-the-art models when navigating real-world clinical nuances, highlighting the limitations of conventional exam-based metrics. Ultimately, QuarkMedBench establishes a rigorous, reproducible yardstick for measuring LLM performance on complex health issues, while its framework inherently supports dynamic knowledge updates to prevent benchmark obsolescence.