# LLM-MINE: Large Language Model based Alzheimer's Disease and Related Dementias Phenotypes Mining from Clinical Notes

arXiv: https://arxiv.org/abs/2603.13673 · HTML: https://mlsanity.com/paper/2603.13673/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 5 of its 31 references that are in the map.
- First posted on arXiv 14 Mar 2026.

## Builds on (most cited first, 5 of 5)

- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Large Language Models are Zero-Shot Reasoners](https://mlsanity.com/paper/2205.11916/) (2022)
- [MedGemma Technical Report](https://mlsanity.com/paper/2507.05201/) (2025)
- [PromptLink: Leveraging Large Language Models for Cross-Source Biomedical Concept Linking](https://mlsanity.com/paper/2405.07500/) (2024)
- [HypKG: Hypergraph-based Knowledge Graph Contextualization for Precision Healthcare](https://mlsanity.com/paper/2507.19726/) (2025)

## Built on by (most cited first, 1 of 1)

- [EHRBench: An Automated and Reliable EHR-based Benchmark for Clinical Decision Making with LLMs](https://mlsanity.com/paper/2605.30637/) (2026)

## Abstract (arXiv)

Accurate extraction of Alzheimer's Disease and Related Dementias (ADRD) phenotypes from electronic health records (EHR) is critical for early-stage detection and disease staging. However, this information is usually embedded in unstructured textual data rather than tabular data, making it difficult to be extracted accurately. We therefore propose LLM-MINE, a Large Language Model-based phenotype mining framework for automatic extraction of ADRD phenotypes from clinical notes. Using two expert-defined phenotype lists, we evaluate the extracted phenotypes by examining their statistical significance across cohorts and their utility for unsupervised disease staging. Chi-square analyses confirm statistically significant phenotype differences across cohorts, with memory impairment being the strongest discriminator. Few-shot prompting with the combined phenotype lists achieves the best clustering performance (ARI=0.290, NMI=0.232), substantially outperforming biomedical NER and dictionary-based baselines. Our results demonstrate that LLM-based phenotype extraction is a promising tool for discovering clinically meaningful ADRD signals from unstructured notes.