# Synthetic Melanoma Image Generation and Evaluation Using Generative Adversarial Networks

arXiv: https://arxiv.org/abs/2603.13497 · HTML: https://mlsanity.com/paper/2603.13497/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 22 of its 49 references that are in the map.
- First posted on arXiv 13 Mar 2026.

## Builds on (most cited first, 22 of 22)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [Progressive Growing of GANs for Improved Quality, Stability, and Variation](https://mlsanity.com/paper/1710.10196/) (2017)
- [Unsupervised Representation Learning with Deep Convolutional Generative Adversarial Networks](https://mlsanity.com/paper/1511.06434/) (2015)
- [Training Generative Adversarial Networks with Limited Data](https://mlsanity.com/paper/2006.06676/) (2020)
- [Alias-Free Generative Adversarial Networks](https://mlsanity.com/paper/2106.12423/) (2021)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [GAN-based Synthetic Medical Image Augmentation for increased CNN Performance in Liver Lesion Classification](https://mlsanity.com/paper/1803.01229/) (2018)
- [A Patient-Centric Dataset of Images and Metadata for Identifying Melanomas Using Clinical Context](https://mlsanity.com/paper/2008.07360/) (2020)
- [Diffusion-based Data Augmentation for Skin Disease Classification: Impact Across Original Medical Datasets to Fully Synthetic Images](https://mlsanity.com/paper/2301.04802/) (2023)
- [(De)Constructing Bias on Skin Lesion Datasets](https://mlsanity.com/paper/1904.08818/) (2019)
- [Identifying Melanoma Images using EfficientNet Ensemble: Winning Solution to the SIIM-ISIC Melanoma Classification Challenge](https://mlsanity.com/paper/2010.05351/) (2020)
- [Single Model Deep Learning on Imbalanced Small Datasets for Skin Lesion Classification](https://mlsanity.com/paper/2102.01284/) (2021)
- [Skin Lesion Synthesis with Generative Adversarial Networks](https://mlsanity.com/paper/1902.03253/) (2019)
- [Derm-T2IM: Harnessing Synthetic Skin Lesion Data via Stable Diffusion Models for Enhanced Skin Disease Classification using ViT and CNN](https://mlsanity.com/paper/2401.05159/) (2024)
- [From Majority to Minority: A Diffusion-based Augmentation for Underrepresented Groups in Skin Lesion Analysis](https://mlsanity.com/paper/2406.18375/) (2024)
- [Fast Adaptive Bilateral Filtering](https://mlsanity.com/paper/1811.02308/) (2018)
- [NeuroMoE: A Transformer-Based Mixture-of-Experts Framework for Multi-Modal Neurological Disorder Classification](https://mlsanity.com/paper/2506.14970/) (2025)
- [Generative Adversarial Networks based Skin Lesion Segmentation](https://mlsanity.com/paper/2305.18164/) (2023)

## Abstract (arXiv)

Melanoma is the most lethal form of skin cancer, and early detection is critical for improving patient outcomes. Although dermoscopy combined with deep learning has advanced automated skin-lesion analysis, progress is hindered by limited access to large, well-annotated datasets and by severe class imbalance, where melanoma images are substantially underrepresented. To address these challenges, we present the first systematic benchmarking study comparing four GAN architectures-DCGAN, StyleGAN2, and two StyleGAN3 variants (T/R)-for high-resolution melanoma-specific synthesis. We train and optimize all models on two expert-annotated benchmarks (ISIC 2018 and ISIC 2020) under unified preprocessing and hyperparameter exploration, with particular attention to R1 regularization tuning. Image quality is assessed through a multi-faceted protocol combining distribution-level metrics (FID), sample-level representativeness (FMD), qualitative dermoscopic inspection, downstream classification with a frozen EfficientNet-based melanoma detector, and independent evaluation by two board-certified dermatologists. StyleGAN2 achieves the best balance of quantitative performance and perceptual quality, attaining FID scores of 24.8 (ISIC 2018) and 7.96 (ISIC 2020) at gamma=0.8. The frozen classifier recognizes 83% of StyleGAN2-generated images as melanoma, while dermatologists distinguish synthetic from real images at only 66.5% accuracy (chance = 50%), with low inter-rater agreement (kappa = 0.17). In a controlled augmentation experiment, adding synthetic melanoma images to address class imbalance improved melanoma detection AUC from 0.925 to 0.945 on a held-out real-image test set. These findings demonstrate that StyleGAN2-generated melanoma images preserve diagnostically relevant features and can provide a measurable benefit for mitigating class imbalance in melanoma-focused machine learning pipelines.