# DDS-UDA: Dual-Domain Synergy for Unsupervised Domain Adaptation in Joint Segmentation of Optic Disc and Optic Cup

arXiv: https://arxiv.org/abs/2603.13345 · HTML: https://mlsanity.com/paper/2603.13345/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 26 of its 55 references that are in the map.
- First posted on arXiv 7 Mar 2026.

## Builds on (most cited first, 26 of 26)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [Encoder-Decoder with Atrous Separable Convolution for Semantic Image Segmentation](https://mlsanity.com/paper/1802.02611/) (2018)
- [CutMix: Regularization Strategy to Train Strong Classifiers with Localizable Features](https://mlsanity.com/paper/1905.04899/) (2019)
- [FDA: Fourier Domain Adaptation for Semantic Segmentation](https://mlsanity.com/paper/2004.05498/) (2020)
- [Domain Adaptation for Medical Image Analysis: A Survey](https://mlsanity.com/paper/2102.09508/) (2021)
- [DAFormer: Improving Network Architectures and Training Strategies for Domain-Adaptive Semantic Segmentation](https://mlsanity.com/paper/2111.14887/) (2021)
- [DACS: Domain Adaptation via Cross-domain Mixed Sampling](https://mlsanity.com/paper/2007.08702/) (2020)
- [Rectifying Pseudo Label Learning via Uncertainty Estimation for Domain Adaptive Semantic Segmentation](https://mlsanity.com/paper/2003.03773/) (2020)
- [Joint Optic Disc and Cup Segmentation Based on Multi-label Deep Network and Polar Transformation](https://mlsanity.com/paper/1801.00926/) (2018)
- [DoFE: Domain-oriented Feature Embedding for Generalizable Fundus Image Segmentation on Unseen Datasets](https://mlsanity.com/paper/2010.06208/) (2020)
- [SynSeg-Net: Synthetic Segmentation Without Target Modality Ground Truth](https://mlsanity.com/paper/1810.06498/) (2018)
- [Unsupervised Cross-Modality Domain Adaptation of ConvNets for Biomedical Image Segmentations with Adversarial Loss](https://mlsanity.com/paper/1804.10916/) (2018)
- [LE-UDA: Label-efficient unsupervised domain adaptation for medical image segmentation](https://mlsanity.com/paper/2212.02078/) (2022)
- [Deep learning for unsupervised domain adaptation in medical imaging: Recent advancements and future perspectives](https://mlsanity.com/paper/2308.01265/) (2023)
- [MUM : Mix Image Tiles and UnMix Feature Tiles for Semi-Supervised Object Detection](https://mlsanity.com/paper/2111.10958/) (2021)
- [UPL-SFDA: Uncertainty-aware Pseudo Label Guided Source-Free Domain Adaptation for Medical Image Segmentation](https://mlsanity.com/paper/2309.10244/) (2023)
- [Consistency Regularization for Generalizable Source-free Domain Adaptation](https://mlsanity.com/paper/2308.01587/) (2023)
- [Domain Adaptive Semantic Segmentation via Regional Contrastive Consistency Regularization](https://mlsanity.com/paper/2110.05170/) (2021)
- [Generalizable Medical Image Segmentation via Random Amplitude Mixup and Domain-Specific Image Restoration](https://mlsanity.com/paper/2208.03901/) (2022)
- [Stable Diffusion Segmentation for Biomedical Images with Single-step Reverse Process](https://mlsanity.com/paper/2406.18361/) (2024)
- [Domain Adaptation for Medical Image Segmentation using Transformation-Invariant Self-Training](https://mlsanity.com/paper/2307.16660/) (2023)
- [Order-preserving Consistency Regularization for Domain Adaptation and Generalization](https://mlsanity.com/paper/2309.13258/) (2023)
- [FPL+: Filtered Pseudo Label-based Unsupervised Cross-Modality Adaptation for 3D Medical Image Segmentation](https://mlsanity.com/paper/2404.04971/) (2024)
- [Medical Image Segmentation with Domain Adaptation: A Survey](https://mlsanity.com/paper/2311.01702/) (2023)
- [Assessing Coarse-to-Fine Deep Learning Models for Optic Disc and Cup Segmentation in Fundus Images](https://mlsanity.com/paper/2209.14383/) (2022)

## Abstract (arXiv)

Convolutional neural networks (CNNs) have achieved exciting performance in joint segmentation of optic disc and optic cup on single-institution datasets. However, their clinical translation is hindered by two major challenges: limited availability of large-scale, high-quality annotations and performance degradation caused by domain shift during deployment across heterogeneous imaging protocols and acquisition platforms. While unsupervised domain adaptation (UDA) provides a way to mitigate these limitations, most existing approaches do not address cross-domain interference and intra-domain generalization within a unified framework. In this paper, we present the Dual-Domain Synergy UDA (DDS-UDA), a novel UDA framework that comprises two key modules. First, a bi-directional cross-domain consistency regularization module is enforced to mitigate cross-domain interference through feature-level semantic information exchange guided by a coarse-to-fine dynamic mask generator, suppressing noise propagation while preserving structural coherence. Second, a frequency-driven intra-domain pseudo label learning module is used to enhance intra-domain generalization by synthesizing spectral amplitude-mixed supervision signals, which ensures high-fidelity feature alignment across domains. Implemented within a teacher-student architecture, DDS-UDA disentangles domain-specific biases from domain-invariant feature-level representations, thereby achieving robust adaptation to heterogeneous imaging environments. We conduct a comprehensive evaluation of our proposed method on two multi-domain fundus image datasets, demonstrating that it outperforms several existing UDA based methods and therefore providing an effective way for optic disc and optic cup segmentation.