# SignalMC-MED: A Multimodal Benchmark for Evaluating Biosignal Foundation Models on Single-Lead ECG and PPG

arXiv: https://arxiv.org/abs/2603.09940 · HTML: https://mlsanity.com/paper/2603.09940/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 14 of its 26 references that are in the map.
- First posted on arXiv 10 Mar 2026.

## Builds on (most cited first, 14 of 14)

- [On the Opportunities and Risks of Foundation Models](https://mlsanity.com/paper/2108.07258/) (2021)
- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [MOMENT: A Family of Open Time-series Foundation Models](https://mlsanity.com/paper/2402.03885/) (2024)
- [Foundation Models for Time Series Analysis: A Tutorial and Survey](https://mlsanity.com/paper/2403.14735/) (2024)
- [Large-scale Training of Foundation Models for Wearable Biosignals](https://mlsanity.com/paper/2312.05409/) (2023)
- [ECG-FM: An Open Electrocardiogram Foundation Model](https://mlsanity.com/paper/2408.05178/) (2024)
- [PaPaGei: Open Foundation Models for Optical Physiological Signals](https://mlsanity.com/paper/2410.20542/) (2024)
- [Pulse-PPG: An Open-Source Field-Trained PPG Foundation Model for Wearable Applications Across Lab and Field Settings](https://mlsanity.com/paper/2502.01108/) (2025)
- [Empowering Time Series Analysis with Foundation Models: A Comprehensive Survey](https://mlsanity.com/paper/2405.02358/) (2024)
- [Boosting Masked ECG-Text Auto-Encoders as Discriminative Learners](https://mlsanity.com/paper/2410.02131/) (2024)
- [Enhancing clinical decision support with physiological waveforms -- a multimodal benchmark in emergency care](https://mlsanity.com/paper/2407.17856/) (2024)
- [BenchECG and xECG: a benchmark and baseline for ECG foundation models](https://mlsanity.com/paper/2509.10151/) (2025)
- [A Systematic Review on Foundation Models for Electrocardiogram Analysis: Initial Strides and Expansive Horizons](https://mlsanity.com/paper/2410.19877/) (2024)
- [Wavelet-Driven Masked Multiscale Reconstruction for PPG Foundation Models](https://mlsanity.com/paper/2601.12215/) (2026)

## Built on by (most cited first, 1 of 1)

- [PPG-Bench: A Unified Benchmark for PPG Foundation Models](https://mlsanity.com/paper/2610.13435/) (2026)

## Abstract (arXiv)

Recent biosignal foundation models (FMs) have demonstrated promising performance across diverse clinical prediction tasks, yet systematic evaluation on long-duration multimodal data remains limited. We introduce SignalMC-MED, a benchmark for evaluating biosignal FMs on synchronized single-lead electrocardiogram (ECG) and photoplethysmogram (PPG) data. Derived from the MC-MED dataset, SignalMC-MED comprises 22,256 visits with 10-minute overlapping ECG and PPG signals, and includes 20 clinically relevant tasks spanning prediction of demographics, emergency department disposition, laboratory value regression, and detection of prior ICD-10 diagnoses. Using this benchmark, we perform a systematic evaluation of representative time-series and biosignal FMs across ECG-only, PPG-only, and ECG + PPG settings. We find that domain-specific biosignal FMs consistently outperform general time-series models, and that multimodal ECG + PPG fusion yields robust improvements over unimodal inputs. Moreover, using the full 10-minute signal consistently outperforms shorter segments, and larger model variants do not reliably outperform smaller ones. Hand-crafted ECG domain features provide a strong baseline and offer complementary value when combined with learned FM representations. Together, these results establish SignalMC-MED as a standardized benchmark and provide practical guidance for evaluating and deploying biosignal FMs.