# Weakly Supervised Teacher-Student Framework with Progressive Pseudo-mask Refinement for Gland Segmentation

arXiv: https://arxiv.org/abs/2603.08605 · HTML: https://mlsanity.com/paper/2603.08605/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 32 of its 53 references that are in the map.
- First posted on arXiv 9 Mar 2026.

## Builds on (most cited first, 30 of 32)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Microsoft COCO: Common Objects in Context](https://mlsanity.com/paper/1405.0312/) (2014)
- [Learning Deep Features for Discriminative Localization](https://mlsanity.com/paper/1512.04150/) (2015)
- [UNet++: A Nested U-Net Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1807.10165/) (2018)
- [SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation](https://mlsanity.com/paper/1511.00561/) (2015)
- [Attention U-Net: Learning Where to Look for the Pancreas](https://mlsanity.com/paper/1804.03999/) (2018)
- [Learning Pixel-level Semantic Affinity with Image-level Supervision for Weakly Supervised Semantic Segmentation](https://mlsanity.com/paper/1803.10464/) (2018)
- [Medical Transformer: Gated Axial-Attention for Medical Image Segmentation](https://mlsanity.com/paper/2102.10662/) (2021)
- [Self-supervised Equivariant Attention Mechanism for Weakly Supervised Semantic Segmentation](https://mlsanity.com/paper/2004.04581/) (2020)
- [ResUNet++: An Advanced Architecture for Medical Image Segmentation](https://mlsanity.com/paper/1911.07067/) (2019)
- [Gland Segmentation in Colon Histology Images: The GlaS Challenge Contest](https://mlsanity.com/paper/1603.00275/) (2016)
- [Weakly-Supervised Semantic Segmentation via Sub-category Exploration](https://mlsanity.com/paper/2008.01183/) (2020)
- [Anti-Adversarially Manipulated Attributions for Weakly and Semi-Supervised Semantic Segmentation](https://mlsanity.com/paper/2103.08896/) (2021)
- [BBAM: Bounding Box Attribution Map for Weakly Supervised Semantic and Instance Segmentation](https://mlsanity.com/paper/2103.08907/) (2021)
- [DCAN: Deep Contour-Aware Networks for Accurate Gland Segmentation](https://mlsanity.com/paper/1604.02677/) (2016)
- [Class Re-Activation Maps for Weakly-Supervised Semantic Segmentation](https://mlsanity.com/paper/2203.00962/) (2022)
- [TransAttUnet: Multi-level Attention-guided U-Net with Transformer for Medical Image Segmentation](https://mlsanity.com/paper/2107.05274/) (2021)
- [KiU-Net: Towards Accurate Segmentation of Biomedical Images using Over-complete Representations](https://mlsanity.com/paper/2006.04878/) (2020)
- [Multi-Layer Pseudo-Supervision for Histopathology Tissue Semantic Segmentation using Patch-level Classification Labels](https://mlsanity.com/paper/2110.08048/) (2021)
- [A Comprehensive Survey on Data Augmentation](https://mlsanity.com/paper/2405.09591/) (2024)
- [Activation Modulation and Recalibration Scheme for Weakly Supervised Semantic Segmentation](https://mlsanity.com/paper/2112.08996/) (2021)
- [Domain Generalization in Computational Pathology: Survey and Guidelines](https://mlsanity.com/paper/2310.19656/) (2023)
- [A Weakly Supervised Consistency-based Learning Method for COVID-19 Segmentation in CT Images](https://mlsanity.com/paper/2007.02180/) (2020)
- [TA-Net: Topology-Aware Network for Gland Segmentation](https://mlsanity.com/paper/2110.14593/) (2021)
- [DA-TransUNet: Integrating Spatial and Channel Dual Attention with Transformer U-Net for Medical Image Segmentation](https://mlsanity.com/paper/2310.12570/) (2023)
- [Online Easy Example Mining for Weakly-supervised Gland Segmentation from Histology Images](https://mlsanity.com/paper/2206.06665/) (2022)
- [SPIDER: A Comprehensive Multi-Organ Supervised Pathology Dataset and Baseline Models](https://mlsanity.com/paper/2503.02876/) (2025)
- [AME-CAM: Attentive Multiple-Exit CAM for Weakly Supervised Segmentation on MRI Brain Tumor](https://mlsanity.com/paper/2306.14505/) (2023)
- [Scribble Hides Class: Promoting Scribble-Based Weakly-Supervised Semantic Segmentation with Its Class Label](https://mlsanity.com/paper/2402.17555/) (2024)
- [HistoMet: A Pan-Cancer Deep Learning Framework for Prognostic Prediction of Metastatic Progression and Site Tropism from Primary Tumor Histopathology](https://mlsanity.com/paper/2602.07608/) (2026)

## Built on by (most cited first, 1 of 1)

- [Morphology-aware deep learning predicts colorectal cancer survival from whole-slide images](https://mlsanity.com/paper/2610.17603/) (2026)

## Abstract (arXiv)

Background and objectives: Colorectal cancer histopathological grading depends on accurate segmentation of glandular structures. Current deep learning approaches rely on large scale pixel level annotations that are labor intensive and difficult to obtain in routine clinical practice. Weakly supervised semantic segmentation offers a promising alternative. However, class activation map based methods often produce incomplete pseudo masks that emphasize highly discriminative regions and fail to supervise unannotated glandular structures. We propose a weakly supervised teacher student framework that leverages sparse pathologist annotations and an Exponential Moving Average stabilized teacher network to generate refined pseudo masks. Methods: The framework integrates confidence based filtering, adaptive fusion of teacher predictions with limited ground truth, and curriculum guided refinement to progressively segment unannotated glandular regions. The method was evaluated on an institutional colorectal cancer cohort from The Ohio State University Wexner Medical Center consisting of 60 hematoxylin and eosin stained whole slide images and on public datasets including the Gland Segmentation dataset, TCGA COAD, TCGA READ, and SPIDER. Results: On the Gland Segmentation dataset the framework achieved a mean Intersection over Union of 80.10 and a mean Dice coefficient of 89.10. Cross cohort evaluation demonstrated robust generalization on TCGA COAD and TCGA READ without additional annotations, while reduced performance on SPIDER reflected domain shift. Conclusions: The proposed framework provides an annotation efficient and generalizable approach for gland segmentation in colorectal histopathology.