# Efficient Chest X-ray Representation Learning via Semantic-Partitioned Contrastive Learning

arXiv: https://arxiv.org/abs/2603.07113 · HTML: https://mlsanity.com/paper/2603.07113/

## Key facts

- Cited by 10 papers in the map (data through 14 Oct 2026).
- Builds on 24 of its 36 references that are in the map.
- First posted on arXiv 7 Mar 2026.

## Builds on (most cited first, 24 of 24)

- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [CheXpert: A Large Chest Radiograph Dataset with Uncertainty Labels and Expert Comparison](https://mlsanity.com/paper/1901.07031/) (2019)
- [ChestX-ray8: Hospital-scale Chest X-ray Database and Benchmarks on Weakly-Supervised Classification and Localization of Common Thorax Diseases](https://mlsanity.com/paper/1705.02315/) (2017)
- [Contrastive Learning of Medical Visual Representations from Paired Images and Text](https://mlsanity.com/paper/2010.00747/) (2020)
- [Making the Most of Text Semantics to Improve Biomedical Vision--Language Processing](https://mlsanity.com/paper/2204.09817/) (2022)
- [Multi-Granularity Cross-modal Alignment for Generalized Medical Visual Representation Learning](https://mlsanity.com/paper/2210.06044/) (2022)
- [MedKLIP: Medical Knowledge Enhanced Language-Image Pre-Training in Radiology](https://mlsanity.com/paper/2301.02228/) (2023)
- [Multi-Modal Masked Autoencoders for Medical Vision-and-Language Pre-Training](https://mlsanity.com/paper/2209.07098/) (2022)
- [Generalized Radiograph Representation Learning via Cross-supervision between Images and Free-text Radiology Reports](https://mlsanity.com/paper/2111.03452/) (2021)
- [Advancing Radiograph Representation Learning with Masked Record Modeling](https://mlsanity.com/paper/2301.13155/) (2023)
- [Comparing to Learn: Surpassing ImageNet Pretraining on Radiographs By Comparing Image Representations](https://mlsanity.com/paper/2007.07423/) (2020)
- [Delving into Masked Autoencoders for Multi-Label Thorax Disease Classification](https://mlsanity.com/paper/2210.12843/) (2022)
- [M-FLAG: Medical Vision-Language Pre-training with Frozen Language Models and Latent Space Geometry Optimization](https://mlsanity.com/paper/2307.08347/) (2023)
- [Large-Scale 3D Medical Image Pre-training with Geometric Context Priors](https://mlsanity.com/paper/2410.09890/) (2024)
- [Enhancing Representation in Radiography-Reports Foundation Model: A Granular Alignment Algorithm Using Masked Contrastive Learning](https://mlsanity.com/paper/2309.05904/) (2023)
- [Segmentation and Vascular Vectorization for Coronary Artery by Geometry-based Cascaded Neural Network](https://mlsanity.com/paper/2305.04208/) (2023)
- [Label-Assemble: Leveraging Multiple Datasets with Partial Labels](https://mlsanity.com/paper/2109.12265/) (2021)
- [CheXWorld: Exploring Image World Modeling for Radiograph Representation Learning](https://mlsanity.com/paper/2504.13820/) (2025)
- [MedViLaM: A multimodal large language model with advanced generalizability and explainability for medical data understanding and generation](https://mlsanity.com/paper/2409.19684/) (2024)
- [TC-SSA: Token Compression via Semantic Slot Aggregation for Gigapixel Pathology Reasoning](https://mlsanity.com/paper/2603.01143/) (2026)
- [One Leaf Reveals the Season: Occlusion-Based Contrastive Learning with Semantic-Aware Views for Efficient Visual Representation](https://mlsanity.com/paper/2411.09858/) (2024)
- [Fewer Tokens, Greater Scaling: Self-Adaptive Visual Bases for Efficient and Expansive Representation Learning](https://mlsanity.com/paper/2511.19515/) (2025)
- [Learning A Multi-Task Transformer Via Unified And Customized Instruction Tuning For Chest Radiograph Interpretation](https://mlsanity.com/paper/2311.01092/) (2023)
- [A foundation model for generalizable disease diagnosis in chest X-ray images](https://mlsanity.com/paper/2410.08861/) (2024)

## Built on by (most cited first, 10 of 10)

- [Beyond Surrogate Gradients: Fully Differentiable Token Pruning for Vision-Language Models](https://mlsanity.com/paper/2605.28051/) (2026)
- [Multimodal Model for Computational Pathology:Representation Learning and Image Compression](https://mlsanity.com/paper/2603.18660/) (2026)
- [A unified multi-task framework enables interpretable chest radiograph analysis](https://mlsanity.com/paper/2606.03417/) (2026)
- [XrayClaw: Cooperative-Competitive Multi-Agent Alignment for Trustworthy Chest X-ray Diagnosis](https://mlsanity.com/paper/2604.02695/) (2026)
- [Stepwise Token Selection for Efficient Multimodal Large Language Models](https://mlsanity.com/paper/2606.16067/) (2026)
- [Learnable Token Sparsification for Efficient Gigapixel Whole Slide Image Reasoning](https://mlsanity.com/paper/2606.08641/) (2026)
- [PathSelect: Sequential Token Selection for Whole Slide Pathology](https://mlsanity.com/paper/2607.23631/) (2026)
- [DiffPrune: differentiable information throttling for token pruning in vision-language models](https://mlsanity.com/paper/2608.01985/) (2026)
- [From Snapshots to Symphonies: The Evolution of Protein Prediction from Static Structures to Generative Dynamics and Multimodal Interactions](https://mlsanity.com/paper/2603.18505/) (2026)
- [StepPrune: Adaptive Sequential Visual Token Selection across Multimodal Large Language Models](https://mlsanity.com/paper/2609.13804/) (2026)

## Abstract (arXiv)

Self-supervised learning (SSL) has emerged as a powerful paradigm for Chest X-ray (CXR) analysis under limited annotations. Yet, existing SSL strategies remain suboptimal for medical imaging. Masked image modeling allocates substantial computation to reconstructing high-frequency background details with limited diagnostic value. Contrastive learning, on the other hand, often depends on aggressive augmentations that risk altering clinically meaningful structures. We introduce Semantic-Partitioned Contrastive Learning (S-PCL), an efficient pre-training framework tailored for CXR representation learning. Instead of reconstructing pixels or relying on heavy augmentations, S-PCL randomly partitions patch tokens from a single CXR into two non-overlapping semantic subsets. Each subset provides a complementary but incomplete view. The encoder must maximize agreement between these partitions, implicitly inferring global anatomical layout and local pathological cues from partial evidence. This semantic partitioning forms an internal bottleneck that enforces long-range dependency modeling and structural coherence. S-PCL eliminates the need for hand-crafted augmentations, auxiliary decoders, and momentum encoders. The resulting architecture is streamlined, computationally efficient, and easy to scale. Extensive experiments on large-scale CXR benchmarks, including ChestX-ray14, CheXpert, RSNA Pneumonia and SIIM-ACR Pneumothorax, show that S-PCL achieves competitive performance while attaining the lowest GFLOPs and superior accuracy among existing SSL approaches.