# Early Warning of Intraoperative Adverse Events via Transformer-Driven Multi-Label Learning

arXiv: https://arxiv.org/abs/2603.05212 · HTML: https://mlsanity.com/paper/2603.05212/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 9 of its 33 references that are in the map.
- First posted on arXiv 5 Mar 2026.

## Builds on (most cited first, 9 of 9)

- [FiLM: Visual Reasoning with a General Conditioning Layer](https://mlsanity.com/paper/1709.07871/) (2017)
- [Informer: Beyond Efficient Transformer for Long Sequence Time-Series Forecasting](https://mlsanity.com/paper/2012.07436/) (2020)
- [Autoformer: Decomposition Transformers with Auto-Correlation for Long-Term Series Forecasting](https://mlsanity.com/paper/2106.13008/) (2021)
- [Class-Balanced Loss Based on Effective Number of Samples](https://mlsanity.com/paper/1901.05555/) (2019)
- [FEDformer: Frequency Enhanced Decomposed Transformer for Long-term Series Forecasting](https://mlsanity.com/paper/2201.12740/) (2022)
- [Learning Imbalanced Datasets with Label-Distribution-Aware Margin Loss](https://mlsanity.com/paper/1906.07413/) (2019)
- [Asymmetric Loss For Multi-Label Classification](https://mlsanity.com/paper/2009.14119/) (2020)
- [Deep Time Series Models: A Comprehensive Survey and Benchmark](https://mlsanity.com/paper/2407.13278/) (2024)
- [Temporal Label Smoothing for Early Event Prediction](https://mlsanity.com/paper/2208.13764/) (2022)

## Abstract (arXiv)

Early warning of intraoperative adverse events plays a vital role in reducing surgical risk and improving patient safety. While deep learning has shown promise in predicting the single adverse event, several key challenges remain: overlooking adverse event dependencies, underutilizing heterogeneous clinical data, and suffering from the class imbalance inherent in medical datasets. To address these issues, we construct the first Multi-label Adverse Events dataset (MuAE) for intraoperative adverse events prediction, covering six critical events. Next, we propose a novel Transformerbased multi-label learning framework (IAENet) that combines an improved Time-Aware Feature-wise Linear Modulation (TAFiLM) module for static covariates and dynamic variables robust fusion and complex temporal dependencies modeling. Furthermore, we introduce a Label-Constrained Reweighting Loss (LCRLoss) with co-occurrence regularization to effectively mitigate intra-event imbalance and enforce structured consistency among frequently co-occurring events. Extensive experiments demonstrate that IAENet consistently outperforms strong baselines on 5, 10, and 15-minute early warning tasks, achieving improvements of +5.05%, +2.82%, and +7.57% on average F1 score. These results highlight the potential of IAENet for supporting intelligent intraoperative decision-making in clinical practice.