# CRESTomics: Analyzing Carotid Plaques in the CREST-2 Trial with a New Additive Classification Model

arXiv: https://arxiv.org/abs/2603.04309 · HTML: https://mlsanity.com/paper/2603.04309/

## Key facts

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- First posted on arXiv 4 Mar 2026.

## Abstract (arXiv)

Accurate characterization of carotid plaques is critical for stroke prevention in patients with carotid stenosis. We analyze 500 plaques from CREST-2, a multi-center clinical trial, to identify radiomics-based markers from B-mode ultrasound images linked with high-risk. We propose a new kernel-based additive model, combining coherence loss with group-sparse regularization for nonlinear classification. Group-wise additive effects of each feature group are visualized using partial dependence plots. Results indicate our method accurately and interpretably assesses plaques, revealing a strong association between plaque texture and clinical risk.