# Can Large Language Models Derive New Knowledge? A Dynamic Benchmark for Biological Knowledge Discovery

arXiv: https://arxiv.org/abs/2603.03322 · HTML: https://mlsanity.com/paper/2603.03322/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 19 of its 33 references that are in the map.
- First posted on arXiv 10 Feb 2026.

## Builds on (most cited first, 19 of 19)

- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [GPQA: A Graduate-Level Google-Proof Q&A Benchmark](https://mlsanity.com/paper/2311.12022/) (2023)
- [MMMU: A Massive Multi-discipline Multimodal Understanding and Reasoning Benchmark for Expert AGI](https://mlsanity.com/paper/2311.16502/) (2023)
- [LiveCodeBench: Holistic and Contamination Free Evaluation of Large Language Models for Code](https://mlsanity.com/paper/2403.07974/) (2024)
- [MMLU-Pro: A More Robust and Challenging Multi-Task Language Understanding Benchmark](https://mlsanity.com/paper/2406.01574/) (2024)
- [A Survey on LLM-as-a-Judge](https://mlsanity.com/paper/2411.15594/) (2024)
- [C-Eval: A Multi-Level Multi-Discipline Chinese Evaluation Suite for Foundation Models](https://mlsanity.com/paper/2305.08322/) (2023)
- [LLMs-as-Judges: A Comprehensive Survey on LLM-based Evaluation Methods](https://mlsanity.com/paper/2412.05579/) (2024)
- [LiveBench: A Challenging, Contamination-Limited LLM Benchmark](https://mlsanity.com/paper/2406.19314/) (2024)
- [On LLMs-Driven Synthetic Data Generation, Curation, and Evaluation: A Survey](https://mlsanity.com/paper/2406.15126/) (2024)
- [Empowering Biomedical Discovery with AI Agents](https://mlsanity.com/paper/2404.02831/) (2024)
- [SciEval: A Multi-Level Large Language Model Evaluation Benchmark for Scientific Research](https://mlsanity.com/paper/2308.13149/) (2023)
- [The Alternative Annotator Test for LLM-as-a-Judge: How to Statistically Justify Replacing Human Annotators with LLMs](https://mlsanity.com/paper/2501.10970/) (2025)
- [OlympicArena: Benchmarking Multi-discipline Cognitive Reasoning for Superintelligent AI](https://mlsanity.com/paper/2406.12753/) (2024)
- [ResearchBench: Benchmarking LLMs in Scientific Discovery via Inspiration-Based Task Decomposition](https://mlsanity.com/paper/2503.21248/) (2025)
- [FutureX: An Advanced Live Benchmark for LLM Agents in Future Prediction](https://mlsanity.com/paper/2508.11987/) (2025)
- [Xiezhi: An Ever-Updating Benchmark for Holistic Domain Knowledge Evaluation](https://mlsanity.com/paper/2306.05783/) (2023)
- [Mathador-LM: A Dynamic Benchmark for Mathematical Reasoning on Large Language Models](https://mlsanity.com/paper/2406.12572/) (2024)
- [Towards Adaptive ML Benchmarks: Web-Agent-Driven Construction, Domain Expansion, and Metric Optimization](https://mlsanity.com/paper/2509.09321/) (2025)

## Built on by (most cited first, 1 of 1)

- [Agentic World Modeling: Foundations, Capabilities, Laws, and Beyond](https://mlsanity.com/paper/2604.22748/) (2026)

## Abstract (arXiv)

Recent advancements in Large Language Model (LLM) agents have demonstrated remarkable potential in automatic knowledge discovery. However, rigorously evaluating an AI's capacity for knowledge discovery remains a critical challenge. Existing benchmarks predominantly rely on static datasets, leading to inevitable data contamination where models have likely seen the evaluation knowledge during training. Furthermore, the rapid release cycles of modern LLMs render static benchmarks quickly outdated, failing to assess the ability to discover truly new knowledge. To address these limitations, we propose DBench-Bio, a dynamic and fully automated benchmark designed to evaluate AI's biological knowledge discovery ability. DBench-Bio employs a three-stage pipeline: (1) data acquisition of rigorous, authoritative paper abstracts; (2) QA extraction utilizing LLMs to synthesize scientific hypothesis questions and corresponding discovery answers; and (3) QA filter to ensure quality based on relevance, clarity, and centrality. We instantiate this pipeline to construct a monthly-updated benchmark covering 12 biomedical sub-domains. Extensive evaluations of SOTA models reveal current limitations in discovering new knowledge. Our work provides the first dynamic, automatic framework for assessing the new knowledge discovery capabilities of AI systems, establishing a living, evolving resource for AI research community to catalyze the development of knowledge discovery.