# Preoperative-to-intraoperative Liver Registration for Laparoscopic Surgery via Latent-Grounded Correspondence Constraints

arXiv: https://arxiv.org/abs/2603.01720 · HTML: https://mlsanity.com/paper/2603.01720/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 8 of its 28 references that are in the map.
- First posted on arXiv 2 Mar 2026.

## Builds on (most cited first, 8 of 8)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [PointNet++: Deep Hierarchical Feature Learning on Point Sets in a Metric Space](https://mlsanity.com/paper/1706.02413/) (2017)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [What Uncertainties Do We Need in Bayesian Deep Learning for Computer Vision?](https://mlsanity.com/paper/1703.04977/) (2017)
- [Deforming Autoencoders: Unsupervised Disentangling of Shape and Appearance](https://mlsanity.com/paper/1806.06503/) (2018)
- [An objective comparison of methods for augmented reality in laparoscopic liver resection by preoperative-to-intraoperative image fusion](https://mlsanity.com/paper/2401.15753/) (2024)
- [Epicardium Prompt-guided Real-time Cardiac Ultrasound Frame-to-volume Registration](https://mlsanity.com/paper/2406.14534/) (2024)
- [Landmark-Free Preoperative-to-Intraoperative Registration in Laparoscopic Liver Resection](https://mlsanity.com/paper/2504.15152/) (2025)

## Abstract (arXiv)

In laparoscopic liver surgery, augmented reality technology enhances intraoperative anatomical guidance by overlaying 3D liver models from preoperative CT/MRI onto laparoscopic 2D views. However, existing registration methods lack explicit modeling of reliable 2D-3D geometric correspondences supported by latent evidence, leading to limited interpretability and potentially unstable alignment in clinical scenarios. In this work, we introduce Land-Reg, a correspondence-driven deformable registration framework that explicitly learns latent-grounded 2D-3D landmark correspondences as an interpretable intermediate representation to bridge cross-modal alignment. For rigid registration, Land-Reg embraces a Cross-modal Latent Alignment module to map multi-modal features into a unified latent space. Further, an Uncertainty-enhanced Overlap Landmark Detector with similarity matching is proposed to robustly estimate explicit 2D-3D landmark correspondences. For non-rigid registration, we design a novel shape-constrained supervision strategy that anchors shape deformation to matched landmarks through reprojection consistency and incorporates local-isometric regularization to alleviate inherent 2D-3D depth ambiguity, while a rendered-mask alignment enforces global shape consistency. Experimental results on the P2ILF dataset demonstrate the superiority of our method on both rigid pose estimation and non-rigid deformation. Our code will be available at https://github.com/cuiruize/Land-Reg.