# Cross-Modal Guidance for Fast Diffusion-Based Computed Tomography

arXiv: https://arxiv.org/abs/2603.01253 · HTML: https://mlsanity.com/paper/2603.01253/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 12 of its 19 references that are in the map.
- First posted on arXiv 1 Mar 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 12 of 12)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Image-to-Image Translation with Conditional Adversarial Networks](https://mlsanity.com/paper/1611.07004/) (2016)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [Improved Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2102.09672/) (2021)
- [Denoising Diffusion Restoration Models](https://mlsanity.com/paper/2201.11793/) (2022)
- [Solving 3D Inverse Problems using Pre-trained 2D Diffusion Models](https://mlsanity.com/paper/2211.10655/) (2022)
- [Provably Robust Score-Based Diffusion Posterior Sampling for Plug-and-Play Image Reconstruction](https://mlsanity.com/paper/2403.17042/) (2024)
- [Prompt-tuning latent diffusion models for inverse problems](https://mlsanity.com/paper/2310.01110/) (2023)
- [Conversion Between CT and MRI Images Using Diffusion and Score-Matching Models](https://mlsanity.com/paper/2209.12104/) (2022)
- [Deep Diffusion Image Prior for Efficient OOD Adaptation in 3D Inverse Problems](https://mlsanity.com/paper/2407.10641/) (2024)
- [A Diffusion Model Translator for Efficient Image-to-Image Translation](https://mlsanity.com/paper/2502.00307/) (2025)
- [Leveraging Multimodal Diffusion Models to Accelerate Imaging with Side Information](https://mlsanity.com/paper/2410.05143/) (2024)

## Built on by (most cited first, 2 of 2)

- [Multimodal Diffusion to Mutually Enhance Polarized Light and Low Resolution EBSD Data](https://mlsanity.com/paper/2604.22212/) (2026)
- [Toward a Foundation Plug-and-Play Prior for Computed Tomography Reconstruction via a Multimodal Diffusion Model](https://mlsanity.com/paper/2608.23190/) (2026)

## Abstract (arXiv)

Diffusion models have emerged as powerful priors for solving inverse problems in computed tomography (CT). In certain applications, such as neutron CT, it can be expensive to collect large amounts of measurements even for a single scan, leading to sparse data sets from which it is challenging to obtain high quality reconstructions even with diffusion models. One strategy to mitigate this challenge is to leverage a complementary, easily available imaging modality; however, such approaches typically require retraining the diffusion model with large datasets. In this work, we propose incorporating an additional modality without retraining the diffusion prior, enabling accelerated imaging of costly modalities. We further examine the impact of imperfect side modalities on cross-modal guidance. Our method is evaluated on sparse-view neutron computed tomography, where reconstruction quality is substantially improved by incorporating X-ray computed tomography of the same samples.