# Antibody: Strengthening Defense Against Harmful Fine-Tuning for Large Language Models via Attenuating Harmful Gradient Influence

arXiv: https://arxiv.org/abs/2603.00498 · HTML: https://mlsanity.com/paper/2603.00498/

## Key facts

- Cited by 6 papers in the map (data through 14 Oct 2026).
- Placed in Safety alignment, refusal and guardrails, one of 12 directions in LLM safety and security.
- Builds on 68 of its 81 references that are in the map.
- First posted on arXiv 28 Feb 2026.

## Placed in

- LLM safety and security / [Safety alignment, refusal and guardrails](https://mlsanity.com/safety/safety-alignment-refusal-and-guardrails/)

## Builds on (most cited first, 30 of 68)

- [LoRA: Low-Rank Adaptation of Large Language Models](https://mlsanity.com/paper/2106.09685/) (2021)
- [LLaMA: Open and Efficient Foundation Language Models](https://mlsanity.com/paper/2302.13971/) (2023)
- [Training Verifiers to Solve Math Word Problems](https://mlsanity.com/paper/2110.14168/) (2021)
- [Direct Preference Optimization: Your Language Model is Secretly a Reward Model](https://mlsanity.com/paper/2305.18290/) (2023)
- [Character-level Convolutional Networks for Text Classification](https://mlsanity.com/paper/1509.01626/) (2015)
- [Qwen2 Technical Report](https://mlsanity.com/paper/2407.10671/) (2024)
- [Gemma 2: Improving Open Language Models at a Practical Size](https://mlsanity.com/paper/2408.00118/) (2024)
- [Sharpness-Aware Minimization for Efficiently Improving Generalization](https://mlsanity.com/paper/2010.01412/) (2020)
- [gpt-oss-120b & gpt-oss-20b Model Card](https://mlsanity.com/paper/2508.10925/) (2025)
- [Fine-tuning Aligned Language Models Compromises Safety, Even When Users Do Not Intend To!](https://mlsanity.com/paper/2310.03693/) (2023)
- [BeaverTails: Towards Improved Safety Alignment of LLM via a Human-Preference Dataset](https://mlsanity.com/paper/2307.04657/) (2023)
- [Safety Alignment Should Be Made More Than Just a Few Tokens Deep](https://mlsanity.com/paper/2406.05946/) (2024)
- [Safety-Tuned LLaMAs: Lessons From Improving the Safety of Large Language Models that Follow Instructions](https://mlsanity.com/paper/2309.07875/) (2023)
- [Shadow Alignment: The Ease of Subverting Safely-Aligned Language Models](https://mlsanity.com/paper/2310.02949/) (2023)
- [Assessing the Brittleness of Safety Alignment via Pruning and Low-Rank Modifications](https://mlsanity.com/paper/2402.05162/) (2024)
- [Safety Fine-Tuning at (Almost) No Cost: A Baseline for Vision Large Language Models](https://mlsanity.com/paper/2402.02207/) (2024)
- [Tamper-Resistant Safeguards for Open-Weight LLMs](https://mlsanity.com/paper/2408.00761/) (2024)
- [Safety Layers in Aligned Large Language Models: The Key to LLM Security](https://mlsanity.com/paper/2408.17003/) (2024)
- [Safe LoRA: the Silver Lining of Reducing Safety Risks when Fine-tuning Large Language Models](https://mlsanity.com/paper/2405.16833/) (2024)
- [Vaccine: Perturbation-aware Alignment for Large Language Models against Harmful Fine-tuning Attack](https://mlsanity.com/paper/2402.01109/) (2024)
- [Fine-tuning can cripple your foundation model; preserving features may be the solution](https://mlsanity.com/paper/2308.13320/) (2023)
- [Keeping LLMs Aligned After Fine-tuning: The Crucial Role of Prompt Templates](https://mlsanity.com/paper/2402.18540/) (2024)
- [Representation Noising: A Defence Mechanism Against Harmful Finetuning](https://mlsanity.com/paper/2405.14577/) (2024)
- [Learning Dynamics of LLM Finetuning](https://mlsanity.com/paper/2407.10490/) (2024)
- [Lisa: Lazy Safety Alignment for Large Language Models against Harmful Fine-tuning Attack](https://mlsanity.com/paper/2405.18641/) (2024)
- [Booster: Tackling Harmful Fine-tuning for Large Language Models via Attenuating Harmful Perturbation](https://mlsanity.com/paper/2409.01586/) (2024)
- [Harmful Fine-tuning Attacks and Defenses for Large Language Models: A Survey](https://mlsanity.com/paper/2409.18169/) (2024)
- [Defending Against Unforeseen Failure Modes with Latent Adversarial Training](https://mlsanity.com/paper/2403.05030/) (2024)
- [Antidote: Post-fine-tuning Safety Alignment for Large Language Models against Harmful Fine-tuning](https://mlsanity.com/paper/2408.09600/) (2024)
- [SEAL: Safety-enhanced Aligned LLM Fine-tuning via Bilevel Data Selection](https://mlsanity.com/paper/2410.07471/) (2024)

## Built on by (most cited first, 6 of 6)

- [A Few Steps Further: Why Defenses Against Malicious Finetuning Erode Under Continued Training](https://mlsanity.com/paper/2605.14605/) (2026)
- [Open-Weight LLM Fine-Tuning Defenses are Susceptible to Simple Attacks](https://mlsanity.com/paper/2605.26526/) (2026)
- [Locking Pretrained Weights via Deep Low-Rank Residual Distillation](https://mlsanity.com/paper/2605.10777/) (2026)
- [Gradient Immunity: Null-Space Resistance to Malicious Fine-Tuning](https://mlsanity.com/paper/2608.05045/) (2026)
- [SafeTune: A Unified Faithful Library for Auditing and Repairing Safety Drift in Fine-Tuned LLMs](https://mlsanity.com/paper/2609.22153/) (2026)
- [Beyond Average Safety: Chance-Constrained LLM Fine-tuning](https://mlsanity.com/paper/2609.29960/) (2026)

## Abstract (arXiv)

Fine-tuning-as-a-service introduces a threat to Large Language Models' safety when service providers fine-tune their models on poisoned user-submitted datasets, a process known as harmful fine-tuning attacks. In this work, we show that by regularizing the gradient contribution of harmful samples encountered during fine-tuning, we can effectively mitigate the impact of harmful fine-tuning attacks. To this end, we introduce Antibody, a defense strategy that first ensures robust safety alignment for the model before fine-tuning, and then applies a safety-preservation learning algorithm during fine-tuning. Specifically, in the alignment stage before fine-tuning, we propose optimizing the model to be in a flat loss region with respect to harmful samples, which makes the safety alignment more resilient to subsequent harmful fine-tuning. Then, in the fine-tuning stage, we design a fine-tuning algorithm that applies a weighting scheme to all samples in each training batch to inhibit the model from learning from harmful samples while encouraging learning from benign samples. Experimental results demonstrate that Antibody successfully mitigates harmful fine-tuning attacks while boosting fine-tuning performance on the user-submitted dataset.