# MINT: Multimodal Imaging-to-Speech Knowledge Transfer for Early Alzheimer's Screening

arXiv: https://arxiv.org/abs/2602.23994 · HTML: https://mlsanity.com/paper/2602.23994/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 11 of its 38 references that are in the map.
- First posted on arXiv 27 Feb 2026.

## Builds on (most cited first, 11 of 11)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [BERT: Pre-training of Deep Bidirectional Transformers for Language Understanding](https://mlsanity.com/paper/1810.04805/) (2018)
- [Learning Transferable Visual Models From Natural Language Supervision](https://mlsanity.com/paper/2103.00020/) (2021)
- [Distilling the Knowledge in a Neural Network](https://mlsanity.com/paper/1503.02531/) (2015)
- [mixup: Beyond Empirical Risk Minimization](https://mlsanity.com/paper/1710.09412/) (2017)
- [XGBoost: A Scalable Tree Boosting System](https://mlsanity.com/paper/1603.02754/) (2016)
- [Optuna: A Next-generation Hyperparameter Optimization Framework](https://mlsanity.com/paper/1907.10902/) (2019)
- [Useful Blunders: Can Automated Speech Recognition Errors Improve Downstream Dementia Classification?](https://mlsanity.com/paper/2401.05551/) (2024)
- [TE-SSL: Time and Event-aware Self Supervised Learning for Alzheimer's Disease Progression Analysis](https://mlsanity.com/paper/2407.06852/) (2024)
- [Joint Self-Supervised and Supervised Contrastive Learning for Multimodal MRI Data: Towards Predicting Abnormal Neurodevelopment](https://mlsanity.com/paper/2312.15064/) (2023)
- [Predicting Cognitive Decline: A Multimodal AI Approach to Dementia Screening from Speech](https://mlsanity.com/paper/2502.08862/) (2025)

## Built on by (most cited first, 1 of 1)

- [Graph-Guided Universum Learning in Generalized Eigenvalue Proximal SVMs for Alzheimer's Disease Classification](https://mlsanity.com/paper/2606.04699/) (2026)

## Abstract (arXiv)

Alzheimer's disease is a progressive neurodegenerative disorder in which mild cognitive impairment (MCI) precedes dementia. Structural MRI provides biomarkers but requires costly infrastructure, limiting population-scale deployment. Speech offers a non-invasive alternative, yet speech-only classifiers are developed independently of neuroimaging and lack biological grounding for CN-versus-MCI classification. We propose MINT (Multimodal Imaging-to-Speech Knowledge Transfer), a three-stage framework that transfers MRI-derived biomarker structure to speech during training. An MRI teacher defines a compact embedding space for CN-versus-MCI classification, while a residual projection head aligns speech representations to this space using a combined geometric loss. The frozen MRI classifier enables imaging-free inference. On ADNI-4, aligned speech achieves performance comparable to speech baselines, while multimodal fusion improves over MRI alone. Ablations identify dropout regularization and self-supervised pretraining as important design choices. To our knowledge, MINT is the first demonstration of MRI-to-speech knowledge transfer for early Alzheimer's screening without imaging at inference.