# ColoDiff: Integrating Dynamic Consistency With Content Awareness for Colonoscopy Video Generation

arXiv: https://arxiv.org/abs/2602.23203 · HTML: https://mlsanity.com/paper/2602.23203/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 37 of its 50 references that are in the map.
- First posted on arXiv 26 Feb 2026.

## Builds on (most cited first, 30 of 37)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Diffusion Models Beat GANs on Image Synthesis](https://mlsanity.com/paper/2105.05233/) (2021)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Scalable Diffusion Models with Transformers](https://mlsanity.com/paper/2212.09748/) (2022)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Taming Transformers for High-Resolution Image Synthesis](https://mlsanity.com/paper/2012.09841/) (2020)
- [Improved Techniques for Training GANs](https://mlsanity.com/paper/1606.03498/) (2016)
- [UMAP: Uniform Manifold Approximation and Projection for Dimension Reduction](https://mlsanity.com/paper/1802.03426/) (2018)
- [Video Diffusion Models](https://mlsanity.com/paper/2204.03458/) (2022)
- [Make-A-Video: Text-to-Video Generation without Text-Video Data](https://mlsanity.com/paper/2209.14792/) (2022)
- [Align your Latents: High-Resolution Video Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2304.08818/) (2023)
- [Towards Accurate Generative Models of Video: A New Metric & Challenges](https://mlsanity.com/paper/1812.01717/) (2018)
- [Tune-A-Video: One-Shot Tuning of Image Diffusion Models for Text-to-Video Generation](https://mlsanity.com/paper/2212.11565/) (2022)
- [Latte: Latent Diffusion Transformer for Video Generation](https://mlsanity.com/paper/2401.03048/) (2024)
- [All are Worth Words: A ViT Backbone for Diffusion Models](https://mlsanity.com/paper/2209.12152/) (2022)
- [Latent Video Diffusion Models for High-Fidelity Long Video Generation](https://mlsanity.com/paper/2211.13221/) (2022)
- [ControlVideo: Training-free Controllable Text-to-Video Generation](https://mlsanity.com/paper/2305.13077/) (2023)
- [StyleGAN-V: A Continuous Video Generator with the Price, Image Quality and Perks of StyleGAN2](https://mlsanity.com/paper/2112.14683/) (2021)
- [LDMVFI: Video Frame Interpolation with Latent Diffusion Models](https://mlsanity.com/paper/2303.09508/) (2023)
- [Video Polyp Segmentation: A Deep Learning Perspective](https://mlsanity.com/paper/2203.14291/) (2022)
- [Improved Techniques for Training Single-Image GANs](https://mlsanity.com/paper/2003.11512/) (2020)
- [Endora: Video Generation Models as Endoscopy Simulators](https://mlsanity.com/paper/2403.11050/) (2024)
- [MoStGAN-V: Video Generation with Temporal Motion Styles](https://mlsanity.com/paper/2304.02777/) (2023)
- [Generative Inbetweening through Frame-wise Conditions-Driven Video Generation](https://mlsanity.com/paper/2412.11755/) (2024)
- [SALI: Short-term Alignment and Long-term Interaction Network for Colonoscopy Video Polyp Segmentation](https://mlsanity.com/paper/2406.13532/) (2024)

## Built on by (most cited first, 2 of 2)

- [From Articulated Kinematics to Routed Visual Control for Action-Conditioned Surgical Video Generation](https://mlsanity.com/paper/2605.08712/) (2026)
- [DepthPilot: From Controllability to Interpretability in Colonoscopy Video Generation](https://mlsanity.com/paper/2604.26232/) (2026)

## Abstract (arXiv)

Colonoscopy video generation delivers dynamic, information-rich data critical for diagnosing intestinal diseases, particularly in data-scarce scenarios. High-quality video generation demands temporal consistency and precise control over clinical attributes, but faces challenges from irregular intestinal structures, diverse disease representations, and various imaging modalities. To this end, we propose ColoDiff, a diffusion-based framework that generates dynamic-consistent and content-aware colonoscopy videos, aiming to alleviate data shortage and assist clinical analysis. At the inter-frame level, our TimeStream module decouples temporal dependency from video sequences through a cross-frame tokenization mechanism, enabling intricate dynamic modeling despite irregular intestinal structures. At the intra-frame level, our Content-Aware module incorporates noise-injected embeddings and learnable prototypes to realize precise control over clinical attributes, breaking through the coarse guidance of diffusion models. Additionally, ColoDiff employs a non-Markovian sampling strategy that cuts steps by over 90% for real-time generation. ColoDiff is evaluated across three public datasets and one hospital database, based on both generation metrics and downstream tasks including disease diagnosis, modality discrimination, bowel preparation scoring, and lesion segmentation. Extensive experiments show ColoDiff generates videos with smooth transitions and rich dynamics. ColoDiff presents an effort in controllable colonoscopy video generation, revealing the potential of synthetic videos in complementing authentic representation and mitigating data scarcity in clinical settings.