# MM-NeuroOnco: A Multimodal Benchmark and Instruction Dataset for MRI-Based Brain Tumor Diagnosis

arXiv: https://arxiv.org/abs/2602.22955 · HTML: https://mlsanity.com/paper/2602.22955/

## Key facts

- Cited by 3 papers in the map (data through 14 Oct 2026).
- Builds on 21 of its 59 references that are in the map.
- First posted on arXiv 26 Feb 2026.

## Builds on (most cited first, 21 of 21)

- [Mask R-CNN](https://mlsanity.com/paper/1703.06870/) (2017)
- [Qwen2.5-VL Technical Report](https://mlsanity.com/paper/2502.13923/) (2025)
- [VQA: Visual Question Answering](https://mlsanity.com/paper/1505.00468/) (2015)
- [LLaVA-Med: Training a Large Language-and-Vision Assistant for Biomedicine in One Day](https://mlsanity.com/paper/2306.00890/) (2023)
- [The RSNA-ASNR-MICCAI BraTS 2021 Benchmark on Brain Tumor Segmentation and Radiogenomic Classification](https://mlsanity.com/paper/2107.02314/) (2021)
- [PathVQA: 30000+ Questions for Medical Visual Question Answering](https://mlsanity.com/paper/2003.10286/) (2020)
- [SLAKE: A Semantically-Labeled Knowledge-Enhanced Dataset for Medical Visual Question Answering](https://mlsanity.com/paper/2102.09542/) (2021)
- [What Clinicians Want: Contextualizing Explainable Machine Learning for Clinical End Use](https://mlsanity.com/paper/1905.05134/) (2019)
- [GREEN: Generative Radiology Report Evaluation and Error Notation](https://mlsanity.com/paper/2405.03595/) (2024)
- [Hulu-Med: A Transparent Generalist Model towards Holistic Medical Vision-Language Understanding](https://mlsanity.com/paper/2510.08668/) (2025)
- [GMAI-MMBench: A Comprehensive Multimodal Evaluation Benchmark Towards General Medical AI](https://mlsanity.com/paper/2408.03361/) (2024)
- [MedTrinity-25M: A Large-scale Multimodal Dataset with Multigranular Annotations for Medicine](https://mlsanity.com/paper/2408.02900/) (2024)
- [The Brain Tumor Segmentation (BraTS) Challenge 2023: Glioma Segmentation in Sub-Saharan Africa Patient Population (BraTS-Africa)](https://mlsanity.com/paper/2305.19369/) (2023)
- [MedCoT: Medical Chain of Thought via Hierarchical Expert](https://mlsanity.com/paper/2412.13736/) (2024)
- [Interactive Medical Image Segmentation: A Benchmark Dataset and Baseline](https://mlsanity.com/paper/2411.12814/) (2024)
- [3D-RAD: A Comprehensive 3D Radiology Med-VQA Dataset with Multi-Temporal Analysis and Diverse Diagnostic Tasks](https://mlsanity.com/paper/2506.11147/) (2025)
- [MedEval: A Multi-Level, Multi-Task, and Multi-Domain Medical Benchmark for Language Model Evaluation](https://mlsanity.com/paper/2310.14088/) (2023)
- [M4CXR: Exploring Multi-task Potentials of Multi-modal Large Language Models for Chest X-ray Interpretation](https://mlsanity.com/paper/2408.16213/) (2024)
- [V2T-CoT: From Vision to Text Chain-of-Thought for Medical Reasoning and Diagnosis](https://mlsanity.com/paper/2506.19610/) (2025)
- [MedThink: Explaining Medical Visual Question Answering via Multimodal Decision-Making Rationale](https://mlsanity.com/paper/2404.12372/) (2024)
- [DentVLM: A Multimodal Vision-Language Model for Comprehensive Dental Diagnosis and Enhanced Clinical Practice](https://mlsanity.com/paper/2509.23344/) (2025)

## Built on by (most cited first, 3 of 3)

- [NeuroQA: A Large-Scale Image-Grounded Benchmark for 3D Brain MRI Understanding](https://mlsanity.com/paper/2605.20525/) (2026)
- [OncoTriad-QA: A Patient-Level Radiology-Pathology-Genomics Benchmark for Pan-Cancer Reasoning](https://mlsanity.com/paper/2608.02615/) (2026)
- [BrainTRACE: Tracing Longitudinal, Multimodal, and Volumetric Evidence in Brain MRI Clinical Reasoning](https://mlsanity.com/paper/2610.06571/) (2026)

## Abstract (arXiv)

Accurate brain tumor diagnosis requires models to not only detect lesions but also generate clinically interpretable reasoning grounded in imaging manifestations, yet existing public datasets remain limited in annotation richness and diagnostic semantics. To bridge this gap, we introduce MM-NeuroOnco, a large-scale multimodal benchmark and instruction-tuning dataset for brain tumor MRI understanding, consisting of 24,726 MRI slices from 20 data sources paired with approximately 200,000 semantically enriched multimodal instructions spanning diverse tumor subtypes and imaging modalities. To mitigate the scarcity and high cost of diagnostic semantic annotations, we develop a multi-model collaborative pipeline for automated medical information completion and quality control, enabling the generation of diagnosis-related semantics beyond mask-only annotations. Building upon this dataset, we further construct MM-NeuroOnco-Bench, a manually annotated evaluation benchmark with a rejection-aware setting to reduce biases inherent in closed-ended question formats. Evaluation across ten representative models shows that even the strongest baseline, Gemini 3 Flash, achieves only 41.88% accuracy on diagnosis-related questions, highlighting the substantial challenges of multimodal brain tumor diagnostic understanding. Leveraging MM-NeuroOnco, we further propose NeuroOnco-GPT, which achieves a 27% absolute accuracy improvement on diagnostic questions following fine-tuning. This result demonstrates the effectiveness of our dataset and benchmark in advancing clinically grounded multimodal diagnostic reasoning. Code and dataset are publicly available at: https://github.com/gfnnnb/MM-NeuroOnco