# IRSDE-Despeckle: A Physics-Grounded Diffusion Model for Generalizable Ultrasound Despeckling

arXiv: https://arxiv.org/abs/2602.22717 · HTML: https://mlsanity.com/paper/2602.22717/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 16 of its 42 references that are in the map.
- First posted on arXiv 26 Feb 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 16 of 16)

- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Flow Straight and Fast: Learning to Generate and Transfer Data with Rectified Flow](https://mlsanity.com/paper/2209.03003/) (2022)
- [SAM 2: Segment Anything in Images and Videos](https://mlsanity.com/paper/2408.00714/) (2024)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [ESRGAN: Enhanced Super-Resolution Generative Adversarial Networks](https://mlsanity.com/paper/1809.00219/) (2018)
- [FFDNet: Toward a Fast and Flexible Solution for CNN based Image Denoising](https://mlsanity.com/paper/1710.04026/) (2017)
- [Learning Deep CNN Denoiser Prior for Image Restoration](https://mlsanity.com/paper/1704.03264/) (2017)
- [Learning a Single Convolutional Super-Resolution Network for Multiple Degradations](https://mlsanity.com/paper/1712.06116/) (2017)
- [Lightweight Image Super-Resolution with Information Multi-distillation Network](https://mlsanity.com/paper/1909.11856/) (2019)
- [Image Restoration with Mean-Reverting Stochastic Differential Equations](https://mlsanity.com/paper/2301.11699/) (2023)
- [A Deeper Look into Aleatoric and Epistemic Uncertainty Disentanglement](https://mlsanity.com/paper/2204.09308/) (2022)
- [Deep Ultrasound Denoising Using Diffusion Probabilistic Models](https://mlsanity.com/paper/2306.07440/) (2023)
- [Speckle2Self: Self-Supervised Ultrasound Speckle Reduction Without Clean Data](https://mlsanity.com/paper/2507.06828/) (2025)
- [SDDPM: Speckle Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2311.10868/) (2023)
- [Ultrasound Signal Processing: From Models to Deep Learning](https://mlsanity.com/paper/2204.04466/) (2022)

## Abstract (arXiv)

Ultrasound imaging is widely used for real-time, noninvasive diagnosis, but speckle and related artifacts reduce image quality and can hinder interpretation. We present a diffusion-based ultrasound despeckling method built on the Image Restoration Stochastic Differential Equations framework. To enable supervised training, we curate large paired datasets by simulating ultrasound images from speckle-free magnetic resonance images using the Matlab UltraSound Toolbox. The proposed model reconstructs speckle-suppressed images while preserving anatomically meaningful edges and contrast. On a held-out simulated test set, our approach consistently outperforms classical filters and recent learning-based despeckling baselines. We quantify prediction uncertainty via cross-model variance and show that higher uncertainty correlates with higher reconstruction error, providing a practical indicator of difficult or failure-prone regions. Finally, we evaluate sensitivity to simulation probe settings and observe domain shift, motivating diversified training and adaptation for robust clinical deployment.