# Reliable XAI Explanations in Sudden Cardiac Death Prediction for Chagas Cardiomyopathy

arXiv: https://arxiv.org/abs/2602.22288 · HTML: https://mlsanity.com/paper/2602.22288/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 5 of its 26 references that are in the map.
- First posted on arXiv 25 Feb 2026.

## Builds on (most cited first, 5 of 5)

- [XGBoost: A Scalable Tree Boosting System](https://mlsanity.com/paper/1603.02754/) (2016)
- ["Why Should I Trust You?": Explaining the Predictions of Any Classifier](https://mlsanity.com/paper/1602.04938/) (2016)
- [On Validating, Repairing and Refining Heuristic ML Explanations](https://mlsanity.com/paper/1907.02509/) (2019)
- [Do Not Trust Additive Explanations](https://mlsanity.com/paper/1903.11420/) (2019)
- [Extending XReason: Formal Explanations for Adversarial Detection](https://mlsanity.com/paper/2501.00537/) (2024)

## Abstract (arXiv)

Sudden cardiac death (SCD) is unpredictable, and its prediction in Chagas cardiomyopathy (CC) remains a significant challenge, especially in patients not classified as high risk. While AI and machine learning models improve risk stratification, their adoption is hindered by a lack of transparency, as they are often perceived as textitblack boxes with unclear decision-making processes. Some approaches apply heuristic explanations without correctness guarantees, leading to mistakes in the decision-making process. To address this, we apply a logic-based explainability method with correctness guarantees to the problem of SCD prediction in CC. This explainability method, applied to an AI classifier with over 95% accuracy and recall, demonstrated strong predictive performance and 100% explanation fidelity. When compared to state-of-the-art heuristic methods, it showed superior consistency and robustness. This approach enhances clinical trust, facilitates the integration of AI-driven tools into practice, and promotes large-scale deployment, particularly in endemic regions where it is most needed.