# Mixed Magnification Aggregation for Generalizable Region-Level Representations in Computational Pathology

arXiv: https://arxiv.org/abs/2602.22176 · HTML: https://mlsanity.com/paper/2602.22176/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 39 of its 53 references that are in the map.
- First posted on arXiv 25 Feb 2026.

## Builds on (most cited first, 30 of 39)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [A Simple Framework for Contrastive Learning of Visual Representations](https://mlsanity.com/paper/2002.05709/) (2020)
- [Masked Autoencoders Are Scalable Vision Learners](https://mlsanity.com/paper/2111.06377/) (2021)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [BEiT: BERT Pre-Training of Image Transformers](https://mlsanity.com/paper/2106.08254/) (2021)
- [Decoupled Weight Decay Regularization](https://mlsanity.com/paper/1711.05101/) (2017)
- [Attention-based Deep Multiple Instance Learning](https://mlsanity.com/paper/1802.04712/) (2018)
- [iBOT: Image BERT Pre-Training with Online Tokenizer](https://mlsanity.com/paper/2111.07832/) (2021)
- [Vision Transformers Need Registers](https://mlsanity.com/paper/2309.16588/) (2023)
- [TransMIL: Transformer based Correlated Multiple Instance Learning for Whole Slide Image Classification](https://mlsanity.com/paper/2106.00908/) (2021)
- [Scaling Vision Transformers to Gigapixel Images via Hierarchical Self-Supervised Learning](https://mlsanity.com/paper/2206.02647/) (2022)
- [Provable Guarantees for Self-Supervised Deep Learning with Spectral Contrastive Loss](https://mlsanity.com/paper/2106.04156/) (2021)
- [BEiT v2: Masked Image Modeling with Vector-Quantized Visual Tokenizers](https://mlsanity.com/paper/2208.06366/) (2022)
- [Context Autoencoder for Self-Supervised Representation Learning](https://mlsanity.com/paper/2202.03026/) (2022)
- [Deep neural network models for computational histopathology: A survey](https://mlsanity.com/paper/1912.12378/) (2019)
- [Multimodal Whole Slide Foundation Model for Pathology](https://mlsanity.com/paper/2411.19666/) (2024)
- [Virchow2: Scaling Self-Supervised Mixed Magnification Models in Pathology](https://mlsanity.com/paper/2408.00738/) (2024)
- [Benchmarking Self-Supervised Learning on Diverse Pathology Datasets](https://mlsanity.com/paper/2212.04690/) (2022)
- [Self supervised contrastive learning for digital histopathology](https://mlsanity.com/paper/2011.13971/) (2020)
- [Decoupled Contrastive Learning](https://mlsanity.com/paper/2110.06848/) (2021)
- [Contrastive Masked Autoencoders are Stronger Vision Learners](https://mlsanity.com/paper/2207.13532/) (2022)
- [Artificial Intelligence for Digital and Computational Pathology](https://mlsanity.com/paper/2401.06148/) (2023)
- [PRISM: A Multi-Modal Generative Foundation Model for Slide-Level Histopathology](https://mlsanity.com/paper/2405.10254/) (2024)
- [Phikon-v2, A large and public feature extractor for biomarker prediction](https://mlsanity.com/paper/2409.09173/) (2024)
- [Hibou: A Family of Foundational Vision Transformers for Pathology](https://mlsanity.com/paper/2406.05074/) (2024)
- [Learning by Reconstruction Produces Uninformative Features For Perception](https://mlsanity.com/paper/2402.11337/) (2024)
- [RudolfV: A Foundation Model by Pathologists for Pathologists](https://mlsanity.com/paper/2401.04079/) (2024)
- [Joint Embedding vs Reconstruction: Provable Benefits of Latent Space Prediction for Self Supervised Learning](https://mlsanity.com/paper/2505.12477/) (2025)
- [CPath-Omni: A Unified Multimodal Foundation Model for Patch and Whole Slide Image Analysis in Computational Pathology](https://mlsanity.com/paper/2412.12077/) (2024)

## Built on by (most cited first, 1 of 1)

- [BigCell: Generating Gigapixel Whole-Slide Images](https://mlsanity.com/paper/2610.14261/) (2026)

## Abstract (arXiv)

In recent years, a standard computational pathology workflow has emerged where whole slide images are cropped into tiles, these tiles are processed using a foundation model, and task-specific models are built using the resulting representations. At least 15 different foundation models have been proposed, and the vast majority are trained exclusively with tiles using the 20× magnification. However, it is well known that certain histologic features can only be discerned with larger context windows and requires a pathologist to zoom in and out when analyzing a whole slide image. Furthermore, creating 224×224 pixel crops at 20× leads to a large number of tiles per slide, which can be gigapixel in size. To more accurately capture multi-resolution features and investigate the possibility of reducing the number of representations per slide, we propose a region-level mixing encoder. Our approach jointly fuses image tile representations of a mixed magnification foundation model using a masked embedding modeling pretraining step. We explore a design space for pretraining the proposed mixed-magnification region aggregators and evaluate our models on transfer to biomarker prediction tasks representing various cancer types. Results demonstrate cancer dependent improvements in predictive performance, highlighting the importance of spatial context and understanding.