# Physiologically Informed Deep Learning: A Multi-Scale Framework for Next-Generation PBPK Modeling

arXiv: https://arxiv.org/abs/2602.18472 · HTML: https://mlsanity.com/paper/2602.18472/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 14 of its 31 references that are in the map.
- First posted on arXiv 9 Feb 2026.

## Builds on (most cited first, 14 of 14)

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- [Lightweight Baselines for Medical Abstract Classification: DistilBERT with Cross-Entropy as a Strong Default](https://mlsanity.com/paper/2510.10025/) (2025)
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## Abstract (arXiv)

Physiologically Based Pharmacokinetic (PBPK) modeling is a cornerstone of model-informed drug development (MIDD), providing a mechanistic framework to predict drug absorption, distribution, metabolism, and excretion (ADME). Despite its utility, adoption is hindered by high computational costs for large-scale simulations, difficulty in parameter identification for complex biological systems, and uncertainty in interspecies extrapolation. In this work, we propose a unified Scientific Machine Learning (SciML) framework that bridges mechanistic rigor and data-driven flexibility. We introduce three contributions: (1) Foundation PBPK Transformers, which treat pharmacokinetic forecasting as a sequence modeling task; (2) Physiologically Constrained Diffusion Models (PCDM), a generative approach that uses a physics-informed loss to synthesize biologically compliant virtual patient populations; and (3) Neural Allometry, a hybrid architecture combining Graph Neural Networks (GNNs) with Neural ODEs to learn continuous cross-species scaling laws. Experiments on synthetic datasets show that the framework reduces physiological violation rates from 2.00% to 0.50% under constraints while offering a path to faster simulation.