# HyPCA-Net: Advancing Multimodal Fusion in Medical Image Analysis

arXiv: https://arxiv.org/abs/2602.16245 · HTML: https://mlsanity.com/paper/2602.16245/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 42 references that are in the map.
- First posted on arXiv 18 Feb 2026.

## Builds on (most cited first, 20 of 20)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [Neural Ordinary Differential Equations](https://mlsanity.com/paper/1806.07366/) (2018)
- [SegNet: A Deep Convolutional Encoder-Decoder Architecture for Image Segmentation](https://mlsanity.com/paper/1511.00561/) (2015)
- [Skin Lesion Analysis Toward Melanoma Detection 2018: A Challenge Hosted by the International Skin Imaging Collaboration (ISIC)](https://mlsanity.com/paper/1902.03368/) (2019)
- [How to train your ViT? Data, Augmentation, and Regularization in Vision Transformers](https://mlsanity.com/paper/2106.10270/) (2021)
- [Balanced Multimodal Learning via On-the-fly Gradient Modulation](https://mlsanity.com/paper/2203.15332/) (2022)
- [Neighborhood Attention Transformer](https://mlsanity.com/paper/2204.07143/) (2022)
- [FcaNet: Frequency Channel Attention Networks](https://mlsanity.com/paper/2012.11879/) (2020)
- [Polyp-PVT: Polyp Segmentation with Pyramid Vision Transformers](https://mlsanity.com/paper/2108.06932/) (2021)
- [MMTM: Multimodal Transfer Module for CNN Fusion](https://mlsanity.com/paper/1911.08670/) (2019)
- [EMCAD: Efficient Multi-scale Convolutional Attention Decoding for Medical Image Segmentation](https://mlsanity.com/paper/2405.06880/) (2024)
- [Reliable Tuberculosis Detection using Chest X-ray with Deep Learning, Segmentation and Visualization](https://mlsanity.com/paper/2007.14895/) (2020)
- [Multi-Modal Mutual Attention and Iterative Interaction for Referring Image Segmentation](https://mlsanity.com/paper/2305.15302/) (2023)
- [POTTER: Pooling Attention Transformer for Efficient Human Mesh Recovery](https://mlsanity.com/paper/2303.13357/) (2023)
- [HAMLET: A Hierarchical Multimodal Attention-based Human Activity Recognition Algorithm](https://mlsanity.com/paper/2008.01148/) (2020)
- [Modality-agnostic Domain Generalizable Medical Image Segmentation by Multi-Frequency in Multi-Scale Attention](https://mlsanity.com/paper/2405.06284/) (2024)
- [Multimodal Fusion Learning with Dual Attention for Medical Imaging](https://mlsanity.com/paper/2412.01248/) (2024)

## Abstract (arXiv)

Multimodal fusion frameworks, which integrate diverse medical imaging modalities (e.g., MRI, CT), have shown great potential in applications such as skin cancer detection, dementia diagnosis, and brain tumor prediction. However, existing multimodal fusion methods face significant challenges. First, they often rely on computationally expensive models, limiting their applicability in low-resource environments. Second, they often employ cascaded attention modules, which potentially increase risk of information loss during inter-module transitions and hinder their capacity to effectively capture robust shared representations across modalities. This restricts their generalization in multi-disease analysis tasks. To address these limitations, we propose a Hybrid Parallel-Fusion Cascaded Attention Network (HyPCA-Net), composed of two core novel blocks: (a) a computationally efficient residual adaptive learning attention block for capturing refined modality-specific representations, and (b) a dual-view cascaded attention block aimed at learning robust shared representations across diverse modalities. Extensive experiments on ten publicly available datasets exhibit that HyPCA-Net significantly outperforms existing leading methods, with improvements of up to 5.2% in performance and reductions of up to 73.1% in computational cost. Code: https://github.com/misti1203/HyPCA-Net.