# Prior-guided Hierarchical Instance-pixel Contrastive Learning for Ultrasound Speckle Noise Suppression

arXiv: https://arxiv.org/abs/2602.13831 · HTML: https://mlsanity.com/paper/2602.13831/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 31 references that are in the map.
- First posted on arXiv 14 Feb 2026.

## Builds on (most cited first, 13 of 13)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [SwinIR: Image Restoration Using Swin Transformer](https://mlsanity.com/paper/2108.10257/) (2021)
- [Restormer: Efficient Transformer for High-Resolution Image Restoration](https://mlsanity.com/paper/2111.09881/) (2021)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [Uformer: A General U-Shaped Transformer for Image Restoration](https://mlsanity.com/paper/2106.03106/) (2021)
- [CSWin Transformer: A General Vision Transformer Backbone with Cross-Shaped Windows](https://mlsanity.com/paper/2107.00652/) (2021)
- [Deep Learning for Segmentation using an Open Large-Scale Dataset in 2D Echocardiography](https://mlsanity.com/paper/1908.06948/) (2019)
- [Low-Dose CT with a Residual Encoder-Decoder Convolutional Neural Network (RED-CNN)](https://mlsanity.com/paper/1702.00288/) (2017)
- [FFCNet: Fourier Transform-Based Frequency Learning and Complex Convolutional Network for Colon Disease Classification](https://mlsanity.com/paper/2207.01287/) (2022)
- [Lesion-Inspired Denoising Network: Connecting Medical Image Denoising and Lesion Detection](https://mlsanity.com/paper/2104.08845/) (2021)

## Abstract (arXiv)

Ultrasound denoising is essential for mitigating speckle-induced degradations, thereby enhancing image quality and improving diagnostic reliability. Nevertheless, because speckle patterns inherently encode both texture and fine anatomical details, effectively suppressing noise while preserving structural fidelity remains a significant challenge. In this study, we propose a prior-guided hierarchical instance-pixel contrastive learning model for ultrasound denoising, designed to promote noise-invariant and structure-aware feature representations by maximizing the separability between noisy and clean samples at both pixel and instance levels. Specifically, a statistics-guided pixel-level contrastive learning strategy is introduced to enhance distributional discrepancies between noisy and clean pixels, thereby improving local structural consistency. Concurrently, a memory bank is employed to facilitate instance-level contrastive learning in the feature space, encouraging representations that more faithfully approximate the underlying data distribution. Furthermore, a hybrid Transformer-CNN architecture is adopted, coupling a Transformer-based encoder for global context modeling with a CNN-based decoder optimized for fine-grained anatomical structure restoration, thus enabling complementary exploitation of long-range dependencies and local texture details. Extensive evaluations on two publicly available ultrasound datasets demonstrate that the proposed model consistently outperforms existing methods, confirming its effectiveness and superiority.