# MindPilot: Closed-loop Visual Stimulation Optimization for Brain Modulation with EEG-guided Diffusion

arXiv: https://arxiv.org/abs/2602.10552 · HTML: https://mlsanity.com/paper/2602.10552/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 37 of its 72 references that are in the map.
- First posted on arXiv 11 Feb 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 30 of 37)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [An Image is Worth 16x16 Words: Transformers for Image Recognition at Scale](https://mlsanity.com/paper/2010.11929/) (2020)
- [DINOv2: Learning Robust Visual Features without Supervision](https://mlsanity.com/paper/2304.07193/) (2023)
- [Momentum Contrast for Unsupervised Visual Representation Learning](https://mlsanity.com/paper/1911.05722/) (2019)
- [Emerging Properties in Self-Supervised Vision Transformers](https://mlsanity.com/paper/2104.14294/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [SDXL: Improving Latent Diffusion Models for High-Resolution Image Synthesis](https://mlsanity.com/paper/2307.01952/) (2023)
- [GLIDE: Towards Photorealistic Image Generation and Editing with Text-Guided Diffusion Models](https://mlsanity.com/paper/2112.10741/) (2021)
- [IP-Adapter: Text Compatible Image Prompt Adapter for Text-to-Image Diffusion Models](https://mlsanity.com/paper/2308.06721/) (2023)
- [Reproducible scaling laws for contrastive language-image learning](https://mlsanity.com/paper/2212.07143/) (2022)
- [Training Diffusion Models with Reinforcement Learning](https://mlsanity.com/paper/2305.13301/) (2023)
- [EEGNet: A Compact Convolutional Network for EEG-based Brain-Computer Interfaces](https://mlsanity.com/paper/1611.08024/) (2016)
- [DPOK: Reinforcement Learning for Fine-tuning Text-to-Image Diffusion Models](https://mlsanity.com/paper/2305.16381/) (2023)
- [Diffusion Self-Guidance for Controllable Image Generation](https://mlsanity.com/paper/2306.00986/) (2023)
- [SDXL-Lightning: Progressive Adversarial Diffusion Distillation](https://mlsanity.com/paper/2402.13929/) (2024)
- [Using Human Feedback to Fine-tune Diffusion Models without Any Reward Model](https://mlsanity.com/paper/2311.13231/) (2023)
- [Controllable Text-to-Image Generation](https://mlsanity.com/paper/1909.07083/) (2019)
- [MindEye2: Shared-Subject Models Enable fMRI-To-Image With 1 Hour of Data](https://mlsanity.com/paper/2403.11207/) (2024)
- [Brain-Like Object Recognition with High-Performing Shallow Recurrent ANNs](https://mlsanity.com/paper/1909.06161/) (2019)
- [Decoding Natural Images from EEG for Object Recognition](https://mlsanity.com/paper/2308.13234/) (2023)
- [Visual Decoding and Reconstruction via EEG Embeddings with Guided Diffusion](https://mlsanity.com/paper/2403.07721/) (2024)
- [MindBridge: A Cross-Subject Brain Decoding Framework](https://mlsanity.com/paper/2404.07850/) (2024)
- [UMBRAE: Unified Multimodal Brain Decoding](https://mlsanity.com/paper/2404.07202/) (2024)
- [MindTuner: Cross-Subject Visual Decoding with Visual Fingerprint and Semantic Correction](https://mlsanity.com/paper/2404.12630/) (2024)
- [BrainVis: Exploring the Bridge between Brain and Visual Signals via Image Reconstruction](https://mlsanity.com/paper/2312.14871/) (2023)
- [Brain Diffusion for Visual Exploration: Cortical Discovery using Large Scale Generative Models](https://mlsanity.com/paper/2306.03089/) (2023)
- [CognitionCapturer: Decoding Visual Stimuli From Human EEG Signal With Multimodal Information](https://mlsanity.com/paper/2412.10489/) (2024)
- [Neuro-3D: Towards 3D Visual Decoding from EEG Signals](https://mlsanity.com/paper/2411.12248/) (2024)
- [BrainSCUBA: Fine-Grained Natural Language Captions of Visual Cortex Selectivity](https://mlsanity.com/paper/2310.04420/) (2023)
- [When Does Perceptual Alignment Benefit Vision Representations?](https://mlsanity.com/paper/2410.10817/) (2024)

## Abstract (arXiv)

Whereas most brain-computer interface research has focused on decoding neural signals into behavior or intent, the reverse challenge-using controlled stimuli to steer brain activity-remains far less understood, particularly in the visual domain. However, designing images that consistently elicit desired neural responses is difficult: subjective states lack clear quantitative measures, and EEG feedback is both noisy and non-differentiable. We introduce MindPilot, the first closed-loop framework that uses EEG signals as optimization feedback to guide naturalistic image generation. Unlike prior work limited to invasive settings or low-level flicker stimuli, MindPilot leverages non-invasive EEG with natural images, treating the brain as a black-box function and employing a pseudo-model guidance mechanism to iteratively refine images without requiring explicit rewards or gradients. We validate MindPilot in both simulation and human experiments, demonstrating (i) efficient retrieval of semantic targets, (ii) closed-loop optimization of EEG features, and (iii) human-subject validations in mental matching and emotion regulation tasks. Our results establish the feasibility of EEG-guided image synthesis and open new avenues for non-invasive closed-loop brain modulation, bidirectional brain-computer interfaces, and neural signal-guided generative modeling.