# Sharp Bounds for Treatment Effect Generalization under Outcome Distribution Shift

arXiv: https://arxiv.org/abs/2602.09595 · HTML: https://mlsanity.com/paper/2602.09595/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- First posted on arXiv 10 Feb 2026.

## Built on by (most cited first, 1 of 1)

- [Improving RCT-Based Treatment Effect Estimation Under Covariate Mismatch via Calibrated Alignment](https://mlsanity.com/paper/2603.19186/) (2026)

## Abstract (arXiv)

Generalizing treatment effects from a randomized trial to a target population requires the assumption that potential outcome distributions are invariant across populations after conditioning on observed covariates. This assumption fails when unmeasured effect modifiers are distributed differently between trial participants and the target population. We develop a sensitivity analysis framework that bounds how much conclusions can change when this transportability assumption is violated. Our approach constrains the likelihood ratio between target and trial outcome densities by a scalar parameter Lambda ≥ 1, with Lambda = 1 recovering standard transportability. For each Lambda, we derive sharp bounds on the target average treatment effect -- the tightest interval guaranteed to contain the true effect under all data-generating processes compatible with the observed data and the sensitivity model. We show that the optimal likelihood ratios have a simple threshold structure, leading to a closed-form greedy algorithm that requires only sorting trial outcomes and redistributing probability mass. The resulting estimator runs in O(n log n) time and is consistent under standard regularity conditions. Simulations demonstrate that our bounds achieve nominal coverage when the true outcome shift falls within the specified Lambda, provide substantially tighter intervals than worst-case bounds, and remain informative across a range of realistic violations of transportability.