# Generative Regression for Left Ventricular Ejection Fraction Estimation from Echocardiography Video

arXiv: https://arxiv.org/abs/2602.08202 · HTML: https://mlsanity.com/paper/2602.08202/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 19 of its 38 references that are in the map.
- First posted on arXiv 9 Feb 2026.

## Builds on (most cited first, 19 of 19)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Denoising Diffusion Implicit Models](https://mlsanity.com/paper/2010.02502/) (2020)
- [Score-Based Generative Modeling through Stochastic Differential Equations](https://mlsanity.com/paper/2011.13456/) (2020)
- [Deep Unsupervised Learning using Nonequilibrium Thermodynamics](https://mlsanity.com/paper/1503.03585/) (2015)
- [Adding Conditional Control to Text-to-Image Diffusion Models](https://mlsanity.com/paper/2302.05543/) (2023)
- [Generative Modeling by Estimating Gradients of the Data Distribution](https://mlsanity.com/paper/1907.05600/) (2019)
- [DPM-Solver: A Fast ODE Solver for Diffusion Probabilistic Model Sampling in Around 10 Steps](https://mlsanity.com/paper/2206.00927/) (2022)
- [Improved Techniques for Training Score-Based Generative Models](https://mlsanity.com/paper/2006.09011/) (2020)
- [DPM-Solver++: Fast Solver for Guided Sampling of Diffusion Probabilistic Models](https://mlsanity.com/paper/2211.01095/) (2022)
- [Maximum Likelihood Training of Score-Based Diffusion Models](https://mlsanity.com/paper/2101.09258/) (2021)
- [CSDI: Conditional Score-based Diffusion Models for Probabilistic Time Series Imputation](https://mlsanity.com/paper/2107.03502/) (2021)
- [Sliced Score Matching: A Scalable Approach to Density and Score Estimation](https://mlsanity.com/paper/1905.07088/) (2019)
- [Deep Learning for Segmentation using an Open Large-Scale Dataset in 2D Echocardiography](https://mlsanity.com/paper/1908.06948/) (2019)
- [Ultrasound Video Transformers for Cardiac Ejection Fraction Estimation](https://mlsanity.com/paper/2107.00977/) (2021)
- [EchoGNN: Explainable Ejection Fraction Estimation with Graph Neural Networks](https://mlsanity.com/paper/2208.14003/) (2022)
- [EchoCoTr: Estimation of the Left Ventricular Ejection Fraction from Spatiotemporal Echocardiography](https://mlsanity.com/paper/2209.04242/) (2022)
- [Light-weight spatio-temporal graphs for segmentation and ejection fraction prediction in cardiac ultrasound](https://mlsanity.com/paper/2207.02549/) (2022)
- [Cyclical Self-Supervision for Semi-Supervised Ejection Fraction Prediction from Echocardiogram Videos](https://mlsanity.com/paper/2210.11291/) (2022)
- [CoReEcho: Continuous Representation Learning for 2D+time Echocardiography Analysis](https://mlsanity.com/paper/2403.10164/) (2024)

## Built on by (most cited first, 1 of 1)

- [The segmentation ceiling: why explicit left-ventricular masks do not improve learned ejection-fraction regression](https://mlsanity.com/paper/2609.19730/) (2026)

## Abstract (arXiv)

Estimating Left Ventricular Ejection Fraction (LVEF) from echocardiograms constitutes an ill-posed inverse problem. Inherent noise, artifacts, and limited viewing angles introduce ambiguity, where a single video sequence may map not to a unique ground truth, but rather to a distribution of plausible physiological values. Prevailing deep learning approaches typically formulate this task as a standard regression problem that minimizes the Mean Squared Error (MSE). However, this paradigm compels the model to learn the conditional expectation, which may yield misleading predictions when the underlying posterior distribution is multimodal or heavy-tailed -- a common phenomenon in pathological scenarios. In this paper, we investigate the paradigm shift from deterministic regression toward generative regression. We propose the Multimodal Conditional Score-based Diffusion model for Regression (MCSDR), a probabilistic framework designed to model the continuous posterior distribution of LVEF conditioned on echocardiogram videos and patient demographic attribute priors. Extensive experiments conducted on the EchoNet-Dynamic, EchoNet-Pediatric, and CAMUS datasets demonstrate that MCSDR achieves state-of-the-art performance. Notably, qualitative analysis reveals that the generation trajectories of our model exhibit distinct behaviors in cases characterized by high noise or significant physiological variability, thereby offering a novel layer of interpretability for AI-aided diagnosis.