# Large language models for spreading dynamics in complex systems

arXiv: https://arxiv.org/abs/2602.08085 · HTML: https://mlsanity.com/paper/2602.08085/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 86 of its 282 references that are in the map.
- First posted on arXiv 8 Feb 2026.

## Builds on (most cited first, 30 of 86)

- [Attention Is All You Need](https://mlsanity.com/paper/1706.03762/) (2017)
- [Language Models are Few-Shot Learners](https://mlsanity.com/paper/2005.14165/) (2020)
- [Training language models to follow instructions with human feedback](https://mlsanity.com/paper/2203.02155/) (2022)
- [Exploring the Limits of Transfer Learning with a Unified Text-to-Text Transformer](https://mlsanity.com/paper/1910.10683/) (2019)
- [DeepSeek-R1: Incentivizing Reasoning Capability in LLMs via Reinforcement Learning](https://mlsanity.com/paper/2501.12948/) (2025)
- [PaLM: Scaling Language Modeling with Pathways](https://mlsanity.com/paper/2204.02311/) (2022)
- [Generative Agents: Interactive Simulacra of Human Behavior](https://mlsanity.com/paper/2304.03442/) (2023)
- [Scaling Instruction-Finetuned Language Models](https://mlsanity.com/paper/2210.11416/) (2022)
- [Self-Instruct: Aligning Language Models with Self-Generated Instructions](https://mlsanity.com/paper/2212.10560/) (2022)
- [A Survey on Hallucination in Large Language Models: Principles, Taxonomy, Challenges, and Open Questions](https://mlsanity.com/paper/2311.05232/) (2023)
- [A Survey on Evaluation of Large Language Models](https://mlsanity.com/paper/2307.03109/) (2023)
- [GLM: General Language Model Pretraining with Autoregressive Blank Infilling](https://mlsanity.com/paper/2103.10360/) (2021)
- [Out of One, Many: Using Language Models to Simulate Human Samples](https://mlsanity.com/paper/2209.06899/) (2022)
- [Visual Adversarial Examples Jailbreak Aligned Large Language Models](https://mlsanity.com/paper/2306.13213/) (2023)
- [Benchmarking Large Language Models in Retrieval-Augmented Generation](https://mlsanity.com/paper/2309.01431/) (2023)
- [Social Simulacra: Creating Populated Prototypes for Social Computing Systems](https://mlsanity.com/paper/2208.04024/) (2022)
- [FakeNewsNet: A Data Repository with News Content, Social Context and Spatialtemporal Information for Studying Fake News on Social Media](https://mlsanity.com/paper/1809.01286/) (2018)
- [Large Language Models Empowered Agent-based Modeling and Simulation: A Survey and Perspectives](https://mlsanity.com/paper/2312.11970/) (2023)
- [A Survey on Self-supervised Learning: Algorithms, Applications, and Future Trends](https://mlsanity.com/paper/2301.05712/) (2023)
- [Simulating Opinion Dynamics with Networks of LLM-based Agents](https://mlsanity.com/paper/2311.09618/) (2023)
- [Networks beyond pairwise interactions: structure and dynamics](https://mlsanity.com/paper/2006.01764/) (2020)
- [Emergent social conventions and collective bias in LLM populations](https://mlsanity.com/paper/2410.08948/) (2024)
- [Large Language Models as Urban Residents: An LLM Agent Framework for Personal Mobility Generation](https://mlsanity.com/paper/2402.14744/) (2024)
- [From News to Forecast: Integrating Event Analysis in LLM-Based Time Series Forecasting with Reflection](https://mlsanity.com/paper/2409.17515/) (2024)
- [Benchmarking large language models for biomedical natural language processing applications and recommendations](https://mlsanity.com/paper/2305.16326/) (2023)
- [RumourEval 2019: Determining Rumour Veracity and Support for Rumours](https://mlsanity.com/paper/1809.06683/) (2018)
- [Can ChatGPT replace StackOverflow? A Study on Robustness and Reliability of Large Language Model Code Generation](https://mlsanity.com/paper/2308.10335/) (2023)
- [Bad Actor, Good Advisor: Exploring the Role of Large Language Models in Fake News Detection](https://mlsanity.com/paper/2309.12247/) (2023)
- [Unveiling the Truth and Facilitating Change: Towards Agent-based Large-scale Social Movement Simulation](https://mlsanity.com/paper/2402.16333/) (2024)
- [MDFEND: Multi-domain Fake News Detection](https://mlsanity.com/paper/2201.00987/) (2022)

## Abstract (arXiv)

Spreading dynamics is a central topic in the physics of complex systems and network science, providing a unified framework for understanding how information, behaviors, and diseases propagate through interactions among system units. In many propagation contexts, spreading processes are influenced by multiple interacting factors, such as information expression patterns, cultural contexts, living environments, cognitive preferences, and public policies, which are difficult to incorporate directly into classical modeling frameworks. Recently, large language models (LLMs) have exhibited strong capabilities in natural language understanding, reasoning, and generation, enabling explicit perception of semantic content and contextual cues in spreading processes, thereby supporting the analysis of the different influencing factors. Beyond serving as external analytical tools, LLMs can also act as interactive agents embedded in propagation systems, potentially influencing spreading pathways and feedback structures. Consequently, the roles and impacts of LLMs on spreading dynamics have become an active and rapidly growing research area across multiple research disciplines. This review provides a comprehensive overview of recent advances in applying LLMs to the study of spreading dynamics across two representative domains: digital epidemics, such as misinformation and rumors, and biological epidemics, including infectious disease outbreaks. We first examine the foundations of epidemic modeling from a complex-systems perspective and discuss how LLM-based approaches relate to traditional frameworks. We then systematically review recent studies from three key perspectives, which are epidemic modeling, epidemic detection and surveillance, and epidemic prediction and management, to clarify how LLMs enhance these areas. Finally, open challenges and potential research directions are discussed.