# Benchmarking and Enhancing PPG-Based Cuffless Blood Pressure Estimation Methods

arXiv: https://arxiv.org/abs/2602.04725 · HTML: https://mlsanity.com/paper/2602.04725/

## Key facts

- Cited by 2 papers in the map (data through 14 Oct 2026).
- Builds on 5 of its 40 references that are in the map.
- First posted on arXiv 4 Feb 2026.

## Builds on (most cited first, 5 of 5)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Rethinking the Inception Architecture for Computer Vision](https://mlsanity.com/paper/1512.00567/) (2015)
- [Efficiently Modeling Long Sequences with Structured State Spaces](https://mlsanity.com/paper/2111.00396/) (2021)
- [Generalizable deep learning for photoplethysmography-based blood pressure estimation -- A Benchmarking Study](https://mlsanity.com/paper/2502.19167/) (2025)
- [NeuroMoE: A Transformer-Based Mixture-of-Experts Framework for Multi-Modal Neurological Disorder Classification](https://mlsanity.com/paper/2506.14970/) (2025)

## Built on by (most cited first, 2 of 2)

- [Attractor-Vascular Coupling Theory: Formal Grounding and Empirical Validation for AAMI-Standard Cuffless Blood Pressure Estimation from Smartphone Photoplethysmography](https://mlsanity.com/paper/2605.10871/) (2026)
- [DMT: Demographic Conditioning, Morphology-Enhanced Transformer for Cuffless Blood Pressure Estimation from PPG Signals](https://mlsanity.com/paper/2606.11125/) (2026)

## Abstract (arXiv)

Cuffless blood pressure screening based on easily acquired photoplethysmography (PPG) signals offers a practical pathway toward scalable cardiovascular health assessment. Despite rapid progress, existing PPG-based blood pressure estimation models have not consistently achieved the established clinical numerical limits such as AAMI/ISO 81060-2, and prior evaluations often lack the rigorous experimental controls necessary for valid clinical assessment. Moreover, the publicly available datasets commonly used are heterogeneous and lack physiologically controlled conditions for fair benchmarking. To enable fair benchmarking under physiologically controlled conditions, we created a standardized benchmarking subset NBPDB comprising 101,453 high-quality PPG segments from 1,103 healthy adults, derived from MIMIC-III and VitalDB. Using this dataset, we systematically benchmarked several state-of-the-art PPG-based models. The results showed that none of the evaluated models met the AAMI/ISO 81060-2 accuracy requirements (mean error < 5 mmHg and standard deviation < 8 mmHg). To improve model accuracy, we modified these models and added patient demographic data such as age, sex, and body mass index as additional inputs. Our modifications consistently improved performance across all models. In particular, the MInception model reduced error by 23% after adding the demographic data and yielded mean absolute errors of 4.75 mmHg (SBP) and 2.90 mmHg (DBP), achieves accuracy comparable to the numerical limits defined by AAMI/ISO accuracy standards. Our results show that existing PPG-based BP estimation models lack clinical practicality under standardized conditions, while incorporating demographic information markedly improves their accuracy and physiological validity.