# LDRNet: Large Deformation Registration Model for Chest CT Registration

arXiv: https://arxiv.org/abs/2602.01812 · HTML: https://mlsanity.com/paper/2602.01812/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 16 of its 30 references that are in the map.
- First posted on arXiv 2 Feb 2026.

## Builds on (most cited first, 16 of 16)

- [Deep Residual Learning for Image Recognition](https://mlsanity.com/paper/1512.03385/) (2015)
- [Adam: A Method for Stochastic Optimization](https://mlsanity.com/paper/1412.6980/) (2014)
- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Densely Connected Convolutional Networks](https://mlsanity.com/paper/1608.06993/) (2016)
- [VoxelMorph: A Learning Framework for Deformable Medical Image Registration](https://mlsanity.com/paper/1809.05231/) (2018)
- [Unsupervised Learning of Probabilistic Diffeomorphic Registration for Images and Surfaces](https://mlsanity.com/paper/1903.03545/) (2019)
- [Large Deformation Diffeomorphic Image Registration with Laplacian Pyramid Networks](https://mlsanity.com/paper/2006.16148/) (2020)
- [Unsupervised Learning for Fast Probabilistic Diffeomorphic Registration](https://mlsanity.com/paper/1805.04605/) (2018)
- [Recursive Cascaded Networks for Unsupervised Medical Image Registration](https://mlsanity.com/paper/1907.12353/) (2019)
- [End-to-End Unsupervised Deformable Image Registration with a Convolutional Neural Network](https://mlsanity.com/paper/1704.06065/) (2017)
- [An Artificial Agent for Robust Image Registration](https://mlsanity.com/paper/1611.10336/) (2016)
- [StereoGAN: Bridging Synthetic-to-Real Domain Gap by Joint Optimization of Domain Translation and Stereo Matching](https://mlsanity.com/paper/2005.01927/) (2020)
- [Real-time 2D/3D Registration via CNN Regression](https://mlsanity.com/paper/1507.07505/) (2015)
- [Fast Predictive Image Registration](https://mlsanity.com/paper/1607.02504/) (2016)
- [Unsupervised Cross-spectral Stereo Matching by Learning to Synthesize](https://mlsanity.com/paper/1903.01078/) (2019)
- [TW-SMNet: Deep Multitask Learning of Tele-Wide Stereo Matching](https://mlsanity.com/paper/1906.04463/) (2019)

## Abstract (arXiv)

Most of the deep learning based medical image registration algorithms focus on brain image registration tasks.Compared with brain registration, the chest CT registration has larger deformation, more complex background and region over-lap. In this paper, we propose a fast unsupervised deep learning method, LDRNet, for large deformation image registration of chest CT images. We first predict a coarse resolution registration field, then refine it from coarse to fine. We propose two innovative technical components: 1) a refine block that is used to refine the registration field in different resolutions, 2) a rigid block that is used to learn transformation matrix from high-level features. We train and evaluate our model on the private dataset and public dataset SegTHOR. We compare our performance with state-of-the-art traditional registration methods as well as deep learning registration models VoxelMorph, RCN, and LapIRN. The results demonstrate that our model achieves state-of-the-art performance for large deformation images registration and is much faster.