# Scale-Cascaded Diffusion Models for Super-Resolution in Medical Imaging

arXiv: https://arxiv.org/abs/2601.23201 · HTML: https://mlsanity.com/paper/2601.23201/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 12 of its 18 references that are in the map.
- First posted on arXiv 30 Jan 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 12 of 12)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [Diffusion Posterior Sampling for General Noisy Inverse Problems](https://mlsanity.com/paper/2209.14687/) (2022)
- [Cascaded Diffusion Models for High Fidelity Image Generation](https://mlsanity.com/paper/2106.15282/) (2021)
- [fastMRI: An Open Dataset and Benchmarks for Accelerated MRI](https://mlsanity.com/paper/1811.08839/) (2018)
- [Deep Laplacian Pyramid Networks for Fast and Accurate Super-Resolution](https://mlsanity.com/paper/1704.03915/) (2017)
- [Analyzing and Improving the Training Dynamics of Diffusion Models](https://mlsanity.com/paper/2312.02696/) (2023)
- [Denoising Diffusion Models for Plug-and-Play Image Restoration](https://mlsanity.com/paper/2305.08995/) (2023)
- [Compressed Sensing using Generative Models](https://mlsanity.com/paper/1703.03208/) (2017)
- [Deep Generative Image Models using a Laplacian Pyramid of Adversarial Networks](https://mlsanity.com/paper/1506.05751/) (2015)
- [A Survey on Diffusion Models for Inverse Problems](https://mlsanity.com/paper/2410.00083/) (2024)
- [Generative Modelling With Inverse Heat Dissipation](https://mlsanity.com/paper/2206.13397/) (2022)
- [Frequency-Guided Posterior Sampling for Diffusion-Based Image Restoration](https://mlsanity.com/paper/2411.15295/) (2024)

## Abstract (arXiv)

Diffusion models have been increasingly used as strong generative priors for solving inverse problems such as super-resolution in medical imaging. However, these approaches typically utilize a diffusion prior trained at a single scale, ignoring the hierarchical scale structure of image data. In this work, we propose to decompose images into Laplacian pyramid scales and train separate diffusion priors for each frequency band. We then develop an algorithm to perform super-resolution that utilizes these priors to progressively refine reconstructions across different scales. Evaluated on brain, knee, and prostate MRI data, our approach both improves perceptual quality over baselines and reduces inference time through smaller coarse-scale networks. Our framework unifies multiscale reconstruction and diffusion priors for medical image super-resolution.