# Blind Ultrasound Image Enhancement via Self-Supervised Physics-Guided Degradation Modeling

arXiv: https://arxiv.org/abs/2601.21856 · HTML: https://mlsanity.com/paper/2601.21856/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Builds on 10 of its 39 references that are in the map.
- First posted on arXiv 29 Jan 2026.

## Builds on (most cited first, 10 of 10)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Swin Transformer: Hierarchical Vision Transformer using Shifted Windows](https://mlsanity.com/paper/2103.14030/) (2021)
- [Gaussian Error Linear Units (GELUs)](https://mlsanity.com/paper/1606.08415/) (2016)
- [Beyond a Gaussian Denoiser: Residual Learning of Deep CNN for Image Denoising](https://mlsanity.com/paper/1608.03981/) (2016)
- [Noise2Void - Learning Denoising from Single Noisy Images](https://mlsanity.com/paper/1811.10980/) (2018)
- [Noise2Self: Blind Denoising by Self-Supervision](https://mlsanity.com/paper/1901.11365/) (2019)
- [Practical Blind Image Denoising via Swin-Conv-UNet and Data Synthesis](https://mlsanity.com/paper/2203.13278/) (2022)
- [Medical image denoising using convolutional denoising autoencoders](https://mlsanity.com/paper/1608.04667/) (2016)
- [Fast and Accurate Estimation of Low-Rank Matrices from Noisy Measurements via Preconditioned Non-Convex Gradient Descent](https://mlsanity.com/paper/2305.17224/) (2023)
- [Deep Learning-based Universal Beamformer for Ultrasound Imaging](https://mlsanity.com/paper/1904.02843/) (2019)

## Built on by (most cited first, 1 of 1)

- [Style-Driven Data Synthesis and Degradation-Aware Enhancement for Ultrasound Image Restoration](https://mlsanity.com/paper/2609.35120/) (2026)

## Abstract (arXiv)

Ultrasound (US) interpretation is hampered by multiplicative speckle, acquisition blur from the point-spread function (PSF), and scanner- and operator-dependent artifacts. Supervised enhancement methods assume access to clean targets or known degradations; conditions rarely met in practice. We present a blind, self-supervised enhancement framework that jointly deconvolves and denoises B-mode images using a Swin Convolutional U-Net trained with a physics-guided degradation model. From each training frame, we extract rotated/cropped patches and synthesize inputs by (i) convolving with a Gaussian PSF surrogate and (ii) injecting noise via either spatial additive Gaussian noise or complex Fourier-domain perturbations that emulate phase/magnitude distortions. For US scans, clean-like targets are obtained via non-local low-rank (NLLR) denoising, removing the need for ground truth; for natural images, the originals serve as targets. Trained and validated on UDIAT~B, JNU-IFM, and XPIE Set-P, and evaluated additionally on a 700-image PSFHS test set, the method achieves the highest PSNR/SSIM across Gaussian and speckle noise levels, with margins that widen under stronger corruption. Relative to MSANN, Restormer, and DnCNN, it typically preserves an extra ~1--4,dB PSNR and 0.05--0.15 SSIM in heavy Gaussian noise, and ~2--5,dB PSNR and 0.05--0.20 SSIM under severe speckle. Controlled PSF studies show reduced FWHM and higher peak gradients, evidence of resolution recovery without edge erosion. Used as a plug-and-play preprocessor, it consistently boosts Dice for fetal head and pubic symphysis segmentation. Overall, the approach offers a practical, assumption-light path to robust US enhancement that generalizes across datasets, scanners, and degradation types.