# WFR-MFM: One-Step Inference for Dynamic Unbalanced Optimal Transport

arXiv: https://arxiv.org/abs/2601.20606 · HTML: https://mlsanity.com/paper/2601.20606/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Flow matching, time series and science, one of 14 directions in Diffusion models.
- Builds on 34 of its 63 references that are in the map.
- First posted on arXiv 28 Jan 2026.

## Placed in

- Diffusion models / [Flow matching, time series and science](https://mlsanity.com/diffusion/flow-matching-time-series-and-science/)

## Builds on (most cited first, 30 of 34)

- [Flow Matching for Generative Modeling](https://mlsanity.com/paper/2210.02747/) (2022)
- [Neural Ordinary Differential Equations](https://mlsanity.com/paper/1806.07366/) (2018)
- [Flow Straight and Fast: Learning to Generate and Transfer Data with Rectified Flow](https://mlsanity.com/paper/2209.03003/) (2022)
- [Consistency Models](https://mlsanity.com/paper/2303.01469/) (2023)
- [Building Normalizing Flows with Stochastic Interpolants](https://mlsanity.com/paper/2209.15571/) (2022)
- [Improving and generalizing flow-based generative models with minibatch optimal transport](https://mlsanity.com/paper/2302.00482/) (2023)
- [Mean Flows for One-step Generative Modeling](https://mlsanity.com/paper/2505.13447/) (2025)
- [Consistency Trajectory Models: Learning Probability Flow ODE Trajectory of Diffusion](https://mlsanity.com/paper/2310.02279/) (2023)
- [One Step Diffusion via Shortcut Models](https://mlsanity.com/paper/2410.12557/) (2024)
- [Multisample Flow Matching: Straightening Flows with Minibatch Couplings](https://mlsanity.com/paper/2304.14772/) (2023)
- [TrajectoryNet: A Dynamic Optimal Transport Network for Modeling Cellular Dynamics](https://mlsanity.com/paper/2002.04461/) (2020)
- [Optimal Entropy-Transport problems and a new Hellinger-Kantorovich distance between positive measures](https://mlsanity.com/paper/1508.07941/) (2015)
- [Improved Mean Flows: On the Challenges of Fastforward Generative Models](https://mlsanity.com/paper/2512.02012/) (2025)
- [Consistency Flow Matching: Defining Straight Flows with Velocity Consistency](https://mlsanity.com/paper/2407.02398/) (2024)
- [Action Matching: Learning Stochastic Dynamics from Samples](https://mlsanity.com/paper/2210.06662/) (2022)
- [On Robustness of Neural Ordinary Differential Equations](https://mlsanity.com/paper/1910.05513/) (2019)
- [Simulation-free Schr"odinger bridges via score and flow matching](https://mlsanity.com/paper/2307.03672/) (2023)
- [Metric Flow Matching for Smooth Interpolations on the Data Manifold](https://mlsanity.com/paper/2405.14780/) (2024)
- [Manifold Interpolating Optimal-Transport Flows for Trajectory Inference](https://mlsanity.com/paper/2206.14928/) (2022)
- [A Computational Framework for Solving Wasserstein Lagrangian Flows](https://mlsanity.com/paper/2310.10649/) (2023)
- [Meta Flow Matching: Integrating Vector Fields on the Wasserstein Manifold](https://mlsanity.com/paper/2408.14608/) (2024)
- [AlphaFlow: Understanding and Improving MeanFlow Models](https://mlsanity.com/paper/2510.20771/) (2025)
- [Unbalancedness in Neural Monge Maps Improves Unpaired Domain Translation](https://mlsanity.com/paper/2311.15100/) (2023)
- [Learning stochastic dynamics from snapshots through regularized unbalanced optimal transport](https://mlsanity.com/paper/2410.00844/) (2024)
- [GENOT: Entropic (Gromov) Wasserstein Flow Matching with Applications to Single-Cell Genomics](https://mlsanity.com/paper/2310.09254/) (2023)
- [SplitMeanFlow: Interval Splitting Consistency in Few-Step Generative Modeling](https://mlsanity.com/paper/2507.16884/) (2025)
- [Joint Velocity-Growth Flow Matching for Single-Cell Dynamics Modeling](https://mlsanity.com/paper/2505.13413/) (2025)
- [Curly Flow Matching for Learning Non-gradient Field Dynamics](https://mlsanity.com/paper/2510.26645/) (2025)
- [FACM: Flow-Anchored Consistency Models](https://mlsanity.com/paper/2507.03738/) (2025)
- [SoFlow: Solution Flow Models for One-Step Generative Modeling](https://mlsanity.com/paper/2512.15657/) (2025)

## Built on by (most cited first, 1 of 1)

- [Multiscale Supervised Unbalanced Optimal Transport Flow Matching](https://mlsanity.com/paper/2605.16529/) (2026)

## Abstract (arXiv)

Reconstructing dynamical evolution from limited observations is a fundamental challenge in single-cell biology, where dynamic unbalanced optimal transport provides a principled framework for modeling coupled transport and mass variation. However, existing approaches rely on trajectory simulation at inference time, making inference a key bottleneck for scalable applications. In this work, we propose a mean-flow framework for unbalanced flow matching that summarizes both transport and mass-growth dynamics over arbitrary time intervals using mean velocity and mass-growth fields, enabling fast one-step generation without trajectory simulation. To solve dynamic unbalanced optimal transport under the Wasserstein-Fisher-Rao geometry, we further build on this framework to develop Wasserstein-Fisher-Rao Mean Flow Matching (WFR-MFM). Across synthetic and real single-cell RNA sequencing datasets, WFR-MFM achieves orders-of-magnitude faster inference than a range of existing baselines while maintaining high predictive accuracy, and enables efficient perturbation response prediction on large synthetic datasets with thousands of conditions.