# MMSF: Multitask and Multimodal Supervised Framework for WSI Classification and Survival Analysis

arXiv: https://arxiv.org/abs/2601.20347 · HTML: https://mlsanity.com/paper/2601.20347/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- First posted on arXiv 28 Jan 2026.

## Abstract (arXiv)

Multimodal evidence is critical in computational pathology: gigapixel whole slide images capture tumor morphology, while patient-level clinical descriptors preserve complementary context for prognosis. Integrating such heterogeneous signals remains challenging because feature spaces exhibit distinct statistics and scales. We introduce MMSF, a multitask and multimodal supervised framework built on a linear-complexity MIL backbone that explicitly decomposes and fuses cross-modal information. MMSF comprises a graph feature extraction module embedding tissue topology at the patch level, a clinical data embedding module standardizing patient attributes, a feature fusion module aligning modality-shared and modality-specific representations, and a Mamba-based MIL encoder with multitask prediction heads. Experiments on CAMELYON16 and TCGA-NSCLC demonstrate 2.1--6.6% accuracy and 2.2--6.9% AUC improvements over competitive baselines, while evaluations on five TCGA survival cohorts yield 7.1--9.8% C-index improvements compared with unimodal methods and 5.6--7.1% over multimodal alternatives.