# Localized Latent Editing for Dose-Response Modeling in Botulinum Toxin Injection Planning

arXiv: https://arxiv.org/abs/2601.19593 · HTML: https://mlsanity.com/paper/2601.19593/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 13 of its 19 references that are in the map.
- First posted on arXiv 27 Jan 2026.

## Builds on (most cited first, 13 of 13)

- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [A Style-Based Generator Architecture for Generative Adversarial Networks](https://mlsanity.com/paper/1812.04948/) (2018)
- [Analyzing and Improving the Image Quality of StyleGAN](https://mlsanity.com/paper/1912.04958/) (2019)
- [MediaPipe: A Framework for Building Perception Pipelines](https://mlsanity.com/paper/1906.08172/) (2019)
- [How far are we from solving the 2D & 3D Face Alignment problem? (and a dataset of 230,000 3D facial landmarks)](https://mlsanity.com/paper/1703.07332/) (2017)
- [Blended Latent Diffusion](https://mlsanity.com/paper/2206.02779/) (2022)
- [InterFaceGAN: Interpreting the Disentangled Face Representation Learned by GANs](https://mlsanity.com/paper/2005.09635/) (2020)
- [StyleRig: Rigging StyleGAN for 3D Control over Portrait Images](https://mlsanity.com/paper/2004.00121/) (2020)
- [Drag Your GAN: Interactive Point-based Manipulation on the Generative Image Manifold](https://mlsanity.com/paper/2305.10973/) (2023)
- [HyperStyle: StyleGAN Inversion with HyperNetworks for Real Image Editing](https://mlsanity.com/paper/2111.15666/) (2021)
- [SCUT-FBP5500: A Diverse Benchmark Dataset for Multi-Paradigm Facial Beauty Prediction](https://mlsanity.com/paper/1801.06345/) (2018)
- [LIME: Localized Image Editing via Attention Regularization in Diffusion Models](https://mlsanity.com/paper/2312.09256/) (2023)
- [Enabling Local Editing in Diffusion Models by Joint and Individual Component Analysis](https://mlsanity.com/paper/2408.16845/) (2024)

## Abstract (arXiv)

Botulinum toxin (Botox) injections are the gold standard for managing facial asymmetry and aesthetic rejuvenation, yet determining the optimal dosage remains largely intuitive, often leading to suboptimal outcomes. We propose a localized latent editing framework that simulates Botulinum Toxin injection effects for injection planning through dose-response modeling. Our key contribution is a Region-Specific Latent Axis Discovery method that learns localized muscle relaxation trajectories in StyleGAN2's latent space, enabling precise control over specific facial regions without global side effects. By correlating these localized latent trajectories with injected toxin units, we learn a predictive dose-response model. We rigorously compare two approaches: direct metric regression versus image-based generative simulation on a clinical dataset of N=360 images from 46 patients. On a hold-out test set, our framework demonstrates moderate-to-strong structural correlations for geometric asymmetry metrics, confirming that the generative model correctly captures the direction of morphological changes. While biological variability limits absolute precision, we introduce a hybrid "Human-in-the-Loop" workflow where clinicians interactively refine simulations, bridging the gap between pathological reconstruction and cosmetic planning.