# TempDiffReg: Temporal Diffusion Model for Non-Rigid 2D-3D Vascular Registration

arXiv: https://arxiv.org/abs/2601.18168 · HTML: https://mlsanity.com/paper/2601.18168/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Placed in Medical imaging and segmentation, one of 14 directions in Diffusion models.
- Builds on 14 of its 29 references that are in the map.
- First posted on arXiv 26 Jan 2026.

## Placed in

- Diffusion models / [Medical imaging and segmentation](https://mlsanity.com/diffusion/medical-imaging-and-segmentation/)

## Builds on (most cited first, 14 of 14)

- [Denoising Diffusion Probabilistic Models](https://mlsanity.com/paper/2006.11239/) (2020)
- [High-Resolution Image Synthesis with Latent Diffusion Models](https://mlsanity.com/paper/2112.10752/) (2021)
- [Hierarchical Text-Conditional Image Generation with CLIP Latents](https://mlsanity.com/paper/2204.06125/) (2022)
- [PIFu: Pixel-Aligned Implicit Function for High-Resolution Clothed Human Digitization](https://mlsanity.com/paper/1905.05172/) (2019)
- [SMPLicit: Topology-aware Generative Model for Clothed People](https://mlsanity.com/paper/2103.06871/) (2021)
- [ViT-V-Net: Vision Transformer for Unsupervised Volumetric Medical Image Registration](https://mlsanity.com/paper/2104.06468/) (2021)
- [gDNA: Towards Generative Detailed Neural Avatars](https://mlsanity.com/paper/2201.04123/) (2022)
- [uniGradICON: A Foundation Model for Medical Image Registration](https://mlsanity.com/paper/2403.05780/) (2024)
- [A survey on deep learning in medical image registration: new technologies, uncertainty, evaluation metrics, and beyond](https://mlsanity.com/paper/2307.15615/) (2023)
- [DiffuStereo: High Quality Human Reconstruction via Diffusion-based Stereo Using Sparse Cameras](https://mlsanity.com/paper/2207.08000/) (2022)
- [Unsupervised CT Metal Artifact Reduction by Plugging Diffusion Priors in Dual Domains](https://mlsanity.com/paper/2308.16742/) (2023)
- [KSS-ICP: Point Cloud Registration based on Kendall Shape Space](https://mlsanity.com/paper/2211.02807/) (2022)
- [DiffuseReg: Denoising Diffusion Model for Obtaining Deformation Fields in Unsupervised Deformable Image Registration](https://mlsanity.com/paper/2410.05234/) (2024)
- [Iterative PnP and its application in 3D-2D vascular image registration for robot navigation](https://mlsanity.com/paper/2310.12551/) (2023)

## Abstract (arXiv)

Transarterial chemoembolization (TACE) is a preferred treatment option for hepatocellular carcinoma and other liver malignancies, yet it remains a highly challenging procedure due to complex intra-operative vascular navigation and anatomical variability. Accurate and robust 2D-3D vessel registration is essential to guide microcatheter and instruments during TACE, enabling precise localization of vascular structures and optimal therapeutic targeting. To tackle this issue, we develop a coarse-to-fine registration strategy. First, we introduce a global alignment module, structure-aware perspective n-point (SA-PnP), to establish correspondence between 2D and 3D vessel structures. Second, we propose TempDiffReg, a temporal diffusion model that performs vessel deformation iteratively by leveraging temporal context to capture complex anatomical variations and local structural changes. We collected data from 23 patients and constructed 626 paired multi-frame samples for comprehensive evaluation. Experimental results demonstrate that the proposed method consistently outperforms state-of-the-art (SOTA) methods in both accuracy and anatomical plausibility. Specifically, our method achieves a mean squared error (MSE) of 0.63 mm and a mean absolute error (MAE) of 0.51 mm in registration accuracy, representing 66.7% lower MSE and 17.7% lower MAE compared to the most competitive existing approaches. It has the potential to assist less-experienced clinicians in safely and efficiently performing complex TACE procedures, ultimately enhancing both surgical outcomes and patient care. Code and data are available at: textcolorbluehttps://github.com/LZH970328/TempDiffReg.git