# MRAG: Benchmarking Retrieval-Augmented Generation for Bio-medicine

arXiv: https://arxiv.org/abs/2601.16503 · HTML: https://mlsanity.com/paper/2601.16503/

## Key facts

- Cited by 4 papers in the map (data through 14 Oct 2026).
- Placed in Medical and biomedical RAG, one of 15 directions in Retrieval-augmented generation.
- Builds on 49 of its 111 references that are in the map.
- First posted on arXiv 23 Jan 2026.

## Placed in

- Retrieval-augmented generation / [Medical and biomedical RAG](https://mlsanity.com/rag/medical-and-biomedical-rag/)

## Builds on (most cited first, 30 of 49)

- [GPT-4 Technical Report](https://mlsanity.com/paper/2303.08774/) (2023)
- [Retrieval-Augmented Generation for Knowledge-Intensive NLP Tasks](https://mlsanity.com/paper/2005.11401/) (2020)
- [Judging LLM-as-a-Judge with MT-Bench and Chatbot Arena](https://mlsanity.com/paper/2306.05685/) (2023)
- [Measuring Massive Multitask Language Understanding](https://mlsanity.com/paper/2009.03300/) (2020)
- [Scaling Laws for Neural Language Models](https://mlsanity.com/paper/2001.08361/) (2020)
- [Self-Refine: Iterative Refinement with Self-Feedback](https://mlsanity.com/paper/2303.17651/) (2023)
- [Qwen Technical Report](https://mlsanity.com/paper/2309.16609/) (2023)
- [Gemini 1.5: Unlocking multimodal understanding across millions of tokens of context](https://mlsanity.com/paper/2403.05530/) (2024)
- [The Curious Case of Neural Text Degeneration](https://mlsanity.com/paper/1904.09751/) (2019)
- [Large Language Models Encode Clinical Knowledge](https://mlsanity.com/paper/2212.13138/) (2022)
- [Challenging BIG-Bench Tasks and Whether Chain-of-Thought Can Solve Them](https://mlsanity.com/paper/2210.09261/) (2022)
- [What Disease does this Patient Have? A Large-scale Open Domain Question Answering Dataset from Medical Exams](https://mlsanity.com/paper/2009.13081/) (2020)
- [PubMedQA: A Dataset for Biomedical Research Question Answering](https://mlsanity.com/paper/1909.06146/) (2019)
- [BEIR: A Heterogenous Benchmark for Zero-shot Evaluation of Information Retrieval Models](https://mlsanity.com/paper/2104.08663/) (2021)
- [Chatbot Arena: An Open Platform for Evaluating LLMs by Human Preference](https://mlsanity.com/paper/2403.04132/) (2024)
- [Few-Shot Parameter-Efficient Fine-Tuning is Better and Cheaper than In-Context Learning](https://mlsanity.com/paper/2205.05638/) (2022)
- [Reading Wikipedia to Answer Open-Domain Questions](https://mlsanity.com/paper/1704.00051/) (2017)
- [C-Eval: A Multi-Level Multi-Discipline Chinese Evaluation Suite for Foundation Models](https://mlsanity.com/paper/2305.08322/) (2023)
- [In-Context Retrieval-Augmented Language Models](https://mlsanity.com/paper/2302.00083/) (2023)
- [Capabilities of GPT-4 on Medical Challenge Problems](https://mlsanity.com/paper/2303.13375/) (2023)
- [Is ChatGPT a General-Purpose Natural Language Processing Task Solver?](https://mlsanity.com/paper/2302.06476/) (2023)
- [CMMLU: Measuring massive multitask language understanding in Chinese](https://mlsanity.com/paper/2306.09212/) (2023)
- [A Survey of Hallucination in Large Foundation Models](https://mlsanity.com/paper/2309.05922/) (2023)
- [RepoCoder: Repository-Level Code Completion Through Iterative Retrieval and Generation](https://mlsanity.com/paper/2303.12570/) (2023)
- [Retrieval-Augmented Generation for AI-Generated Content: A Survey](https://mlsanity.com/paper/2402.19473/) (2024)
- [Benchmarking Retrieval-Augmented Generation for Medicine](https://mlsanity.com/paper/2402.13178/) (2024)
- [RAFT: Adapting Language Model to Domain Specific RAG](https://mlsanity.com/paper/2403.10131/) (2024)
- [Capabilities of Gemini Models in Medicine](https://mlsanity.com/paper/2404.18416/) (2024)
- [MedCPT: Contrastive Pre-trained Transformers with Large-scale PubMed Search Logs for Zero-shot Biomedical Information Retrieval](https://mlsanity.com/paper/2307.00589/) (2023)
- [PaperQA: Retrieval-Augmented Generative Agent for Scientific Research](https://mlsanity.com/paper/2312.07559/) (2023)

## Built on by (most cited first, 4 of 4)

- [Evaluating ChatGPT on Medical Information Extraction Tasks: Performance, Explainability and Beyond](https://mlsanity.com/paper/2601.21767/) (2026)
- [Pursuing Best Industrial Practices for Retrieval-Augmented Generation in the Medical Domain](https://mlsanity.com/paper/2602.03368/) (2026)
- [ACL: Aligned Contrastive Learning Improves BERT and Multi-exit BERT Fine-tuning](https://mlsanity.com/paper/2602.03563/) (2026)
- [A Generative Model for Joint Multiple Intent Detection and Slot Filling](https://mlsanity.com/paper/2602.08322/) (2026)

## Abstract (arXiv)

While Retrieval-Augmented Generation (RAG) has been swiftly adopted in scientific and clinical QA systems, a comprehensive evaluation benchmark in the medical domain is lacking. To address this gap, we introduce the Medical Retrieval-Augmented Generation (MRAG) benchmark, covering various tasks in English and Chinese languages, and building a corpus with Wikipedia and Pubmed. Additionally, we develop the MRAG-Toolkit, facilitating systematic exploration of different RAG components. Our experiments reveal that: (a) RAG enhances LLM reliability across MRAG tasks. (b) the performance of RAG systems is influenced by retrieval approaches, model sizes, and prompting strategies. (c) While RAG improves usefulness and reasoning quality, LLM responses may become slightly less readable for long-form questions. We will release the MRAG-Bench's dataset and toolkit with CCBY-4.0 license upon acceptance, to facilitate applications from both academia and industry.