# FeTTL: Federated Template and Task Learning for Multi-Institutional Medical Imaging

arXiv: https://arxiv.org/abs/2601.16302 · HTML: https://mlsanity.com/paper/2601.16302/

## Key facts

- No citing papers in the map yet (data through 14 Oct 2026).
- Builds on 20 of its 36 references that are in the map.
- First posted on arXiv 22 Jan 2026.

## Builds on (most cited first, 20 of 20)

- [U-Net: Convolutional Networks for Biomedical Image Segmentation](https://mlsanity.com/paper/1505.04597/) (2015)
- [Very Deep Convolutional Networks for Large-Scale Image Recognition](https://mlsanity.com/paper/1409.1556/) (2014)
- [Communication-Efficient Learning of Deep Networks from Decentralized Data](https://mlsanity.com/paper/1602.05629/) (2016)
- [Federated Optimization in Heterogeneous Networks](https://mlsanity.com/paper/1812.06127/) (2018)
- [Arbitrary Style Transfer in Real-time with Adaptive Instance Normalization](https://mlsanity.com/paper/1703.06868/) (2017)
- [StarGAN v2: Diverse Image Synthesis for Multiple Domains](https://mlsanity.com/paper/1912.01865/) (2019)
- [StarGAN: Unified Generative Adversarial Networks for Multi-Domain Image-to-Image Translation](https://mlsanity.com/paper/1711.09020/) (2017)
- [FedBN: Federated Learning on Non-IID Features via Local Batch Normalization](https://mlsanity.com/paper/2102.07623/) (2021)
- [Universal Style Transfer via Feature Transforms](https://mlsanity.com/paper/1705.08086/) (2017)
- [FedDG: Federated Domain Generalization on Medical Image Segmentation via Episodic Learning in Continuous Frequency Space](https://mlsanity.com/paper/2103.06030/) (2021)
- [REFUGE Challenge: A Unified Framework for Evaluating Automated Methods for Glaucoma Assessment from Fundus Photographs](https://mlsanity.com/paper/1910.03667/) (2019)
- [Multi-site fMRI Analysis Using Privacy-preserving Federated Learning and Domain Adaptation: ABIDE Results](https://mlsanity.com/paper/2001.05647/) (2020)
- [NVIDIA FLARE: Federated Learning from Simulation to Real-World](https://mlsanity.com/paper/2210.13291/) (2022)
- [Fair Federated Medical Image Segmentation via Client Contribution Estimation](https://mlsanity.com/paper/2303.16520/) (2023)
- [Cancer Metastasis Detection With Neural Conditional Random Field](https://mlsanity.com/paper/1806.07064/) (2018)
- [FedHarmony: Unlearning Scanner Bias with Distributed Data](https://mlsanity.com/paper/2205.15970/) (2022)
- [Patchwork Learning: A Paradigm Towards Integrative Analysis across Diverse Biomedical Data Sources](https://mlsanity.com/paper/2305.06217/) (2023)
- [Quantitative Metrics for Benchmarking Medical Image Harmonization](https://mlsanity.com/paper/2402.04426/) (2024)
- [CXR Segmentation by AdaIN-based Domain Adaptation and Knowledge Distillation](https://mlsanity.com/paper/2104.05892/) (2021)
- [Data Alchemy: Mitigating Cross-Site Model Variability Through Test Time Data Calibration](https://mlsanity.com/paper/2407.13632/) (2024)

## Abstract (arXiv)

Federated learning enables collaborative model training across geographically distributed medical centers while preserving data privacy. However, domain shifts and heterogeneity in data often lead to a degradation in model performance. Medical imaging applications are particularly affected by variations in acquisition protocols, scanner types, and patient populations. To address these issues, we introduce Federated Template and Task Learning (FeTTL), a novel framework designed to harmonize multi-institutional medical imaging data in federated environments. FeTTL learns a global template together with a task model to align data distributions among clients. We evaluated FeTTL on two challenging and diverse multi-institutional medical imaging tasks: retinal fundus optical disc segmentation and histopathological metastasis classification. Experimental results show that FeTTL significantly outperforms the state-of-the-art federated learning baselines (p-values <0.002) for optical disc segmentation and classification of metastases from multi-institutional data. Our experiments further highlight the importance of jointly learning the template and the task. These findings suggest that FeTTL offers a principled and extensible solution for mitigating distribution shifts in federated learning, supporting robust model deployment in real-world, multi-institutional environments.