# NeuroMamba: Multi-Perspective Feature Interaction with Visual Mamba for Neuron Segmentation

arXiv: https://arxiv.org/abs/2601.15929 · HTML: https://mlsanity.com/paper/2601.15929/

## Key facts

- Cited by 1 papers in the map (data through 14 Oct 2026).
- Placed in Mamba for medical image analysis, one of 10 directions in State-space sequence models (S4, Mamba).
- Builds on 19 of its 43 references that are in the map.
- First posted on arXiv 22 Jan 2026.

## Placed in

- State-space sequence models (S4, Mamba) / [Mamba for medical image analysis](https://mlsanity.com/ssm/mamba-for-medical-image-analysis/)

## Builds on (most cited first, 19 of 19)

- [Mamba: Linear-Time Sequence Modeling with Selective State Spaces](https://mlsanity.com/paper/2312.00752/) (2023)
- [Vision Mamba: Efficient Visual Representation Learning with Bidirectional State Space Model](https://mlsanity.com/paper/2401.09417/) (2024)
- [UNETR: Transformers for 3D Medical Image Segmentation](https://mlsanity.com/paper/2103.10504/) (2021)
- [Swin UNETR: Swin Transformers for Semantic Segmentation of Brain Tumors in MRI Images](https://mlsanity.com/paper/2201.01266/) (2022)
- [U-Mamba: Enhancing Long-range Dependency for Biomedical Image Segmentation](https://mlsanity.com/paper/2401.04722/) (2024)
- [VideoMamba: State Space Model for Efficient Video Understanding](https://mlsanity.com/paper/2403.06977/) (2024)
- [SegMamba: Long-range Sequential Modeling Mamba For 3D Medical Image Segmentation](https://mlsanity.com/paper/2401.13560/) (2024)
- [LocalMamba: Visual State Space Model with Windowed Selective Scan](https://mlsanity.com/paper/2403.09338/) (2024)
- [EfficientVMamba: Atrous Selective Scan for Light Weight Visual Mamba](https://mlsanity.com/paper/2403.09977/) (2024)
- [PlainMamba: Improving Non-Hierarchical Mamba in Visual Recognition](https://mlsanity.com/paper/2403.17695/) (2024)
- [Strip Pooling: Rethinking Spatial Pooling for Scene Parsing](https://mlsanity.com/paper/2003.13328/) (2020)
- [MambaAD: Exploring State Space Models for Multi-class Unsupervised Anomaly Detection](https://mlsanity.com/paper/2404.06564/) (2024)
- [Voxel Mamba: Group-Free State Space Models for Point Cloud based 3D Object Detection](https://mlsanity.com/paper/2406.10700/) (2024)
- [Superhuman Accuracy on the SNEMI3D Connectomics Challenge](https://mlsanity.com/paper/1706.00120/) (2017)
- [Multi-Scale VMamba: Hierarchy in Hierarchy Visual State Space Model](https://mlsanity.com/paper/2405.14174/) (2024)
- [Self-Supervised Neuron Segmentation with Multi-Agent Reinforcement Learning](https://mlsanity.com/paper/2310.04148/) (2023)
- [ViM-UNet: Vision Mamba for Biomedical Segmentation](https://mlsanity.com/paper/2404.07705/) (2024)
- [Learning and Segmenting Dense Voxel Embeddings for 3D Neuron Reconstruction](https://mlsanity.com/paper/1909.09872/) (2019)
- [Cross-Classification Clustering: An Efficient Multi-Object Tracking Technique for 3-D Instance Segmentation in Connectomics](https://mlsanity.com/paper/1812.01157/) (2018)

## Built on by (most cited first, 1 of 1)

- [NeuroRefiner: Morphology-Aware Multi-Agent Refinement for 3D Fluorescence Microscopy Neuron Segmentation](https://mlsanity.com/paper/2608.09636/) (2026)

## Abstract (arXiv)

Neuron segmentation is the cornerstone of reconstructing comprehensive neuronal connectomes, which is essential for deciphering the functional organization of the brain. The irregular morphology and densely intertwined structures of neurons make this task particularly challenging. Prevailing CNN-based methods often fail to resolve ambiguous boundaries due to the lack of long-range context, whereas Transformer-based methods suffer from boundary imprecision caused by the loss of voxel-level details during patch partitioning. To address these limitations, we propose NeuroMamba, a multi-perspective framework that exploits the linear complexity of Mamba to enable patch-free global modeling and synergizes this with complementary local feature modeling, thereby efficiently capturing long-range dependencies while meticulously preserving fine-grained voxel details. Specifically, we design a channel-gated Boundary Discriminative Feature Extractor (BDFE) to enhance local morphological cues. Complementing this, we introduce the Spatial Continuous Feature Extractor (SCFE), which integrates a resolution-aware scanning mechanism into the Visual Mamba architecture to adaptively model global dependencies across varying data resolutions. Finally, a cross-modulation mechanism synergistically fuses these multi-perspective features. Our method demonstrates state-of-the-art performance across four public EM datasets, validating its exceptional adaptability to both anisotropic and isotropic resolutions. The source code will be made publicly available.